Journal Club 2019





Monday, March. 29th, 2019 - Bahtiyar Yilmaz

Cell Host Microbe. 2019 Jan 9;25(1):128-139.e5. doi: 10.1016/j.chom.2018.12.003.
Commensal Enterobacteriaceae Protect against Salmonella Colonization through Oxygen Competition.
Litvak Y, Mon KKZ, Nguyen H, Chanthavixay G, Liou M, Velazquez EM, Kutter L, Alcantara MA, Byndloss MX, Tiffany CR, Walker GT, Faber F1, Zhu Y, Bronner DN, Byndloss AJ, Tsolis RM, Zhou H, Bäumler AJ.

PubMed Link

Immunity. 2019 Jan 15;50(1):212-224.e4. doi: 10.1016/j.immuni.2018.12.015.
Microbiotas from Humans with Inflammatory Bowel Disease Alter the Balance of Gut Th17 and RORγt+ Regulatory T Cells and Exacerbate Colitis in Mice.
Britton GJ, Contijoch EJ, Mogno I, Vennaro OH, Llewellyn SR, Ng R, Li Z, Mortha A, Merad M, Das A, Gevers D, McGovern DPB, Singh N, Braun J, Jacobs JP, Clemente JC, Grinspan A, Sands BE, Colombel JF, Dubinsky MC, Faith JJ.

PubMed Link


Monday, March. 18th, 2019 - Cristina Kalbermatter

Science. 2018 Jan 12;359(6372):177-186. doi: 10.1126/science.aah6499.
The epigenetic control of stemness in CD8+ T cell fate commitment.
Pace L, Goudot C, Zueva E, Gueguen P, Burgdorf N, Waterfall JJ, Quivy JP, Almouzni G, Amigorena S.

PubMed Link

Science. 2019 Mar 8;363(6431). pii: eaat4042. doi: 10.1126/science.aat4042.
Endocytosis of commensal antigens by intestinal epithelial cells regulates mucosal T cell homeostasis.
Ladinsky MS, Araujo LP, Zhang X, Veltri J, Galan-Diez M, Soualhi S, Lee C, Irie K, Pinker EY, Narushima S, Bandyopadhyay S, Nagayama M, Elhenawy W, Coombes BK, Ferraris RP, Honda K, Iliev ID, Gao N, Bjorkman PJ, Ivanov II.

PubMed Link


Monday, March. 15th, 2019 - Jakob Zimmermann

J Exp Med. 2019 Apr 1;216(4):728-742. doi: 10.1084/jem.20180871. Epub 2019 Feb 27.
Antigen-presenting ILC3 regulate T cell-dependent IgA responses to colonic mucosal bacteria.
Melo-Gonzalez F, Kammoun H, Evren E, Dutton EE, Papadopoulou M, Bradford BM, Tanes C, Fardus-Reid F, Swann JR, Bittinger K, Mabbott NA, Vallance BA, Willinger T, Withers DR, Hepworth MR.

PubMed Link

Nature. 2019 Feb;566(7743):249-253. doi: 10.1038/s41586-019-0899-7. Epub 2019 Jan 30.
Interleukin-22 protects intestinal stem cells against genotoxic stress.
Gronke K, Hernández PP, Zimmermann J, Klose CSN, Kofoed-Branzk M, Guendel F, Witkowski M, Tizian C, Amann L, Schumacher F, Glatt H, Triantafyllopoulou A, Diefenbach A.

PubMed Link


Monday, March. 4th, 2019 - Hai Li

Nature. 2019 Jan;565(7741):600-605. doi: 10.1038/s41586-019-0878-z. Epub 2019 Jan 23.
A defined commensal consortium elicits CD8 T cells and anti-cancer immunity.
Tanoue T, Morita S, Plichta DR, Skelly AN, Suda W, Sugiura Y, Narushima S, Vlamakis H, Motoo I, Sugita K, Shiota A, Takeshita K, Yasuma-Mitobe K, Riethmacher D, Kaisho T, Norman JM, Mucida D, Suematsu M, Yaguchi T, Bucci V, Inoue T, Kawakami Y, Olle B, Roberts B, Hattori M, Xavier RJ, Atarashi K, Honda K.

PubMed Link

Science. 2019 Feb 15;363(6428):748-753. doi: 10.1126/science.aau8475.
BCR-dependent lineage plasticity in mature B cells.
Graf R, Seagal J, Otipoby KL, Lam KP, Ayoub S, Zhang B, Sander S, Chu VT, Rajewsky K.

PubMed Link


Friday, March. 1st, 2019 - Francesca Ronchi

Nature. 2019 Feb;566(7742):110-114. doi: 10.1038/s41586-019-0884-1. Epub 2019 Jan 23.
GPR31-dependent dendrite protrusion of intestinal CX3CR1+ cells by bacterial metabolites.
Morita N, Umemoto E, Fujita S, Hayashi A, Kikuta J, Kimura I, Haneda T, Imai T, Inoue A, Mimuro H, Maeda Y, Kayama H, Okumura R, Aoki J, Okada N, Kida T, Ishii M, Nabeshima R, Takeda K.

PubMed Link

Nature. 2019 Feb;566(7742):115-119. doi: 10.1038/s41586-018-0849-9. Epub 2019 Jan 30.
Gut intraepithelial T cells calibrate metabolism and accelerate cardiovascular disease.
He S, Kahles F, Rattik S, Nairz M, McAlpine CS, Anzai A, Selgrade D, Fenn AM, Chan CT, Mindur JE, Valet C, Poller WC, Halle L, Rotllan N, Iwamoto Y, Wojtkiewicz GR, Weissleder R, Libby P, Fernández-Hernando C, Drucker DJ, Nahrendorf M, Swirski FK.

PubMed Link


Monday, Feb. 8th, 2019 - Tim Rollenske

Cell. 2019 Apr 4;177(2):492-493. doi: 10.1016/j.cell.2019.03.037. No abstract available.
Recirculating Intestinal IgA-Producing Cells Regulate Neuroinflammation via IL-10.
Rojas OL, Pröbstel AK, Porfilio EA, Wang AA, Charabati M, Sun T, Lee DSW, Galicia G, Ramaglia V, Ward LA, Leung LYT, Najafi G, Khaleghi K, Garcillán B, Li A, Besla R, Naouar I, Cao EY, Chiaranunt P, Burrows K, Robinson HG, Allanach JR, Yam J, Luck H, Campbell DJ, Allman D, Brooks DG, Tomura M, Baumann R, Zamvil SS, Bar-Or A, Horwitz MS, Winer DA, Mortha A, Mackay F, Prat A, Osborne LC, Robbins C, Baranzini SE, Gommerman JL.

PubMed Link

Nat Med. 2019 Feb;25(2):249-254. doi: 10.1038/s41591-018-0326-x. Epub 2019 Jan 28.
Identification of preexisting adaptive immunity to Cas9 proteins in humans.
Charlesworth CT, Deshpande PS, Dever DP, Camarena J, Lemgart VT, Cromer MK, Vakulskas CA, Collingwood MA, Zhang L, Bode NM, Behlke MA, Dejene B, Cieniewicz B, Romano R, Lesch BJ, Gomez-Ospina N, Mantri S, Pavel-Dinu M, Weinberg KI, Porteus MH.

PubMed Link


Monday, Jan. 21st, 2019 - Disha Tandon

Appl Microbiol Biotechnol. 2018 Dec;102(23):10219-10230. doi: 10.1007/s00253-018-9378-6. Epub 2018 Oct 9.
Alterations in the diversity and composition of mice gut microbiota by lytic or temperate gut phage treatment.
Bao HD, Pang MD, Olaniran A, Zhang XH, Zhang H, Zhou Y, Sun LC, Schmidt S, Wang R.

PubMed Link

Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20236-41. doi: 10.1073/pnas.1319470110. Epub 2013 Nov 20.
Gnotobiotic mouse model of phage-bacterial host dynamics in the human gut.
Reyes A, Wu M, McNulty NP, Rohwer FL, Gordon JI.

PubMed Link


Monday, Jan. 18th, 2019 - Julien Limenitakis

Microbiome. 2019 Jan 3;7(1):1. doi: 10.1186/s40168-018-0604-3.
Host immunoglobulin G selectively identifies pathobionts in pediatric inflammatory bowel diseases.
Armstrong H, Alipour M, Valcheva R, Bording-Jorgensen M, Jovel J, Zaidi D, Shah P, Lou Y, Ebeling C, Mason AL, Lafleur D, Jerasi J, Wong GK, Madsen K, Carroll MW, Huynh HQ, Dieleman LA, Wine E.

PubMed Link

BioRxiv
High-throughput targeted long-read single cell sequencing reveals the clonal and transcriptional landscape of lymphocytes
Mandeep Singh, Ghamdan Al-Eryani, ProfileShaun Carswell, James M. Ferguson, James Blackburn, ProfileKirston Barton, Daniel Roden, Fabio Luciani, Tri Phan, Simon Junankar, Katherine Jackson, Christopher C. Goodnow, Martin A. Smith, Alexander Swarbrick



Monday, Jan. 7th, 2019 - Anna Wenning

Nat Commun. 2018 Dec 7;9(1):5238. doi: 10.1038/s41467-018-07716-7.
PDL2+ CD11b+ dermal dendritic cells capture topical antigen through hair follicles to prime LAP+ Tregs.
Tordesillas L, Lozano-Ojalvo D, Dunkin D, Mondoulet L, Agudo J, Merad M, Sampson H, Berin MC.

PubMed Link

Nat Commun. 2018 Dec 21;9(1):5424. doi: 10.1038/s41467-018-07803-9.
The gut microbiome is required for full protection against acute arsenic toxicity in mouse models.
Coryell M, McAlpine M, Pinkham NV, McDermott TR, Walk ST.

PubMed Link

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