Journal Club 2018




Monday, July 23rd, 2018 - Hai Li

Nat Commun. 2018 Mar 7;9(1):975. doi: 10.1038/s41467-018-03070-w.
Early-life exposure to low-dose oxidants can increase longevity via microbiome remodelling in Drosophila.
Obata F, Fons CO, Gould AP.

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Cell. 2018 Jun 14;173(7):1742-1754.e17. doi: 10.1016/j.cell.2018.05.008.
Transient Osmotic Perturbation Causes Long-Term Alteration to the Gut Microbiota.
Tropini C, Moss EL, Merrill BD, Ng KM, Higginbottom SK, Casavant EP, Gonzalez CG, Fremin B, Bouley DM, Elias JE, Bhatt AS, Huang KC, Sonnenburg JL.

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Monday, July 16th, 2018 - Mohana

Toxicol Lett. 2018 Apr;286:80-88. doi: 10.1016/j.toxlet.2018.01.011. Epub 2018 Jan 31.
Effect of subchronic exposure to inorganic arsenic on the structure and function of the intestinal epithelium.
Chiocchetti GM, Vélez D, Devesa V.

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Sci Rep. 2017 Aug 2;7(1):7140. doi: 10.1038/s41598-017-07271-z.
Arsenic exposure impels CD4 commitment in thymus and suppress T cell cytokine secretion by increasing regulatory T cells.
Gera R, Singh V, Mitra S, Sharma AK, Singh A, Dasgupta A, Singh D, Kumar M, Jagdale P, Patnaik S, Ghosh D.

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Monday, July 2nd, 2018 - Jakob

Immunity. 2018 Jun 19;48(6):1245-1257.e9. doi: 10.1016/j.immuni.2018.04.013. Epub 2018 May 29.
Extrathymically Generated Regulatory T Cells Establish a Niche for Intestinal Border-Dwelling Bacteria and Affect Physiologic Metabolite Balance.
Campbell C, Dikiy S, Bhattarai SK, Chinen T, Matheis F, Calafiore M, Hoyos B, Hanash A, Mucida D, Bucci V, Rudensky AY.

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Science. 2018 May 18;360(6390):795-800. doi: 10.1126/science.aaq0926. 
Gut microbiota utilize immunoglobulin A for mucosal colonization.
Donaldson GP, Ladinsky MS, Yu KB, Sanders JG, Yoo BB, Chou WC, Conner ME, Earl AM, Knight R, Bjorkman PJ, Mazmanian SK.

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Monday, June 18th, 2018 - Matheus

Plant Cell. 2015 Nov;27(11):3175-89. doi: 10.1105/tpc.15.00585. Epub 2015 Nov 3.
Plants Release Precursors of Histone Deacetylase Inhibitors to Suppress Growth of Competitors.
Venturelli S, Belz RG, Kämper A, Berger A, von Horn K, Wegner A, Böcker A, Zabulon G, Langenecker T, Kohlbacher O, Barneche F, Weigel D, Lauer UM, Bitzer M, Becker C.

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Gastroenterology. 2018 Apr 21. pii: S0016-5085(18)30478-5. doi: 10.1053/j.gastro.2018.04.017. [Epub ahead of print]
Disruption of Epithelial HDAC3 in Intestine Prevents Diet-induced Obesity in Mice.
Whitt J, Woo V, Lee P, Moncivaiz J, Haberman Y, Denson L, Tso P, Alenghat T.

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Monday, June 11th, 2018 - Mercedes

Immunity. 2018 May 24. pii: S1074-7613(18)30181-X. doi: 10.1016/j.immuni.2018.04.012. [Epub ahead of print]
The Tumor Necrosis Factor Superfamily Member RANKL Suppresses Effector Cytokine Production in Group 3 Innate Lymphoid Cells.
Bando JK, Gilfillan S, Song C, McDonald KG, Huang SC, Newberry RD, Kobayashi Y, Allan DSJ, Carlyle JR, Cella M, Colonna M.

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Nat Immunol. 2018 Jun;19(6):561-570. doi: 10.1038/s41590-018-0108-0. Epub 2018 May 18.
Semaphorin 6D reverse signaling controls macrophage lipid metabolism and anti-inflammatory polarization.
Kang S, Nakanishi Y, Kioi Y, Okuzaki D, Kimura T, Takamatsu H, Koyama S, Nojima S, Nishide M, Hayama Y, Kinehara Y, Kato Y, Nakatani T, Shimogori T, Takagi J, Toyofuku T, Kumanogoh A.

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Monday, June 4th, 2018 - Olivier

Immunity. 2018 Mar 20;48(3):584-598.e5. doi: 10.1016/j.immuni.2018.02.015. Epub 2018 Mar 13.
Sensing Microbial Viability through Bacterial RNA Augments T Follicular Helper Cell and Antibody Responses.
Barbet G, Sander LE, Geswell M, Leonardi I, Cerutti A, Iliev I, Blander JM.

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Front Immunol. 2018 Mar 19;9:551. doi: 10.3389/fimmu.2018.00551. eCollection 2018.
Cholinergic Activation Enhances Resistance to Oral Salmonella Infection by Modulating Innate Immune Defense Mechanisms at the Intestinal Barrier.
Al-Barazie RM, Bashir GH, Qureshi MM, Mohamed YA, Al-Sbiei A, Tariq S, Lammers WJ, Al-Ramadi BK, Fernandez-Cabezudo MJ.

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Monday, May. 28th, 2018 - Julien

Cell Host Microbe. 2018 May 9;23(5):653-660.e5. doi: 10.1016/j.chom.2018.04.009.
Early-Life Antibiotic-Driven Dysbiosis Leads to Dysregulated Vaccine Immune Responses in Mice.
Lynn MA, Tumes DJ, Choo JM, Sribnaia A, Blake SJ, Leong LEX, Young GP, Marshall HS, Wesselingh SL, Rogers GB, Lynn DJ.

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Nature. 2018 May;557(7705):434-438. doi: 10.1038/s41586-018-0092-4. Epub 2018 May 9.
An exclusive metabolic niche enables strain engraftment in the gut microbiota.
Shepherd ES, DeLoache WC, Pruss KM, Whitaker WR, Sonnenburg JL.

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Monday, May. 7th, 2018 - Stephanie

Sci Transl Med. 2018 May 2;10(439). pii: eaan1217. doi: 10.1126/scitranslmed.aan1217.
Microbial ecology perturbation in human IgA deficiency.
Fadlallah J, El Kafsi H, Sterlin D, Juste C, Parizot C, Dorgham K, Autaa G, Gouas D, Almeida M, Lepage P, Pons N, Le Chatelier E, Levenez F, Kennedy S, Galleron N, de Barros JP, Malphettes M, Galicier L, Boutboul D, Mathian A, Miyara M, Oksenhendler E, Amoura Z, Doré J, Fieschi C, Ehrlich SD, Larsen M, Gorochov G.

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Monday, April. 23rd, 2018 - Bahtiyar Yilmaz

Nat Microbiol. 2018 Mar;3(3):337-346. doi: 10.1038/s41564-017-0089-z. Epub 2018 Jan 8.
Dynamics of metatranscription in the inflammatory bowel disease gut microbiome.
Schirmer M, Franzosa EA, Lloyd-Price J, McIver LJ, Schwager R, Poon TW, Ananthakrishnan AN, Andrews E, Barron G, Lake K, Prasad M, Sauk J, Stevens B, Wilson RG, Braun J, Denson LA, Kugathasan S, McGovern DPB, Vlamakis H, Xavier RJ, Huttenhower C.

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Nat Microbiol. 2018 Apr;3(4):514-522. doi: 10.1038/s41564-018-0123-9. Epub 2018 Mar 19.
Nutritional preferences of human gut bacteria reveal their metabolic idiosyncrasies.
Tramontano M, Andrejev S, Pruteanu M, Klünemann M, Kuhn M, Galardini M, Jouhten P, Zelezniak A, Zeller G, Bork P, Typas A, Patil KR.

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Monday, April. 23rd, 2018 - Francesca Ronchi

Cell Host Microbe. 2018 Apr 11;23(4):458-469.e5. doi: 10.1016/j.chom.2018.03.011.
Small Intestine Microbiota Regulate Host Digestive and Absorptive Adaptive Responses to Dietary Lipids.
Martinez-Guryn K, Hubert N, Frazier K, Urlass S, Musch MW, Ojeda P, Pierre JF, Miyoshi J, Sontag TJ, Cham CM, Reardon CA, Leone V, Chang EB.

PubMed Link

Cell Host Microbe. 2018 Apr 11;23(4):447-457.e4. doi: 10.1016/j.chom.2018.03.002. Epub 2018 Mar 22.
Nutritional Support from the Intestinal Microbiota Improves Hematopoietic Reconstitution after Bone Marrow Transplantation in Mice.
Staffas A, Burgos da Silva M, Slingerland AE, Lazrak A, Bare CJ, Holman CD, Docampo MD, Shono Y, Durham B, Pickard AJ, Cross JR, Stein-Thoeringer C, Velardi E, Tsai JJ, Jahn L1, Jay H, Lieberman S, Smith OM, Pamer EG, Peled JU, Cohen DE, Jenq RR, van den Brink MRM.

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Monday, April. 16th, 2018 - Hai Li

Cell Host Microbe. 2018 Mar 14;23(3):302-311.e3. doi: 10.1016/j.chom.2018.01.005. Epub 2018 Feb 22.
Commensal Microbes Induce Serum IgA Responses that Protect against Polymicrobial Sepsis.
Wilmore JR, Gaudette BT, Gomez Atria D, Hashemi T, Jones DD, Gardner CA, Cole SD, Misic AM, Beiting DP, Allman D.

PubMed Link

Cell Metab. 2018 Mar 6;27(3):559-571.e5. doi: 10.1016/j.cmet.2018.01.005. Epub 2018 Feb 15.
An Integrated Understanding of the Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet on Hepatic Steatosis in Humans.
Mardinoglu A, Wu H, Bjornson E, Zhang C, Hakkarainen A, Räsänen SM, Lee S, Mancina RM, Bergentall M, Pietiläinen KH, Söderlund S, Matikainen N, Ståhlman M, Bergh PO, Adiels M, Piening BD, Granér M, Lundbom N, Williams KJ, Romeo S, Nielsen J, Snyder M, Uhlén M, Bergström G, Perkins R, Marschall HU, Bäckhed F, Taskinen MR, Borén J.

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Monday, April. 9th, 2018 - Jakob Zimmermann

J Exp Med. 2018 Apr 2;215(4):1069-1077. doi: 10.1084/jem.20170518. Epub 2018 Feb 22.
IL-7-dependent maintenance of ILC3s is required for normal entry of lymphocytes into lymph nodes.
Yang J, Cornelissen F, Papazian N, Reijmers RM, Llorian M, Cupedo T, Coles M, Seddon B.

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Nat Immunol. 2018 Apr;19(4):386-396. doi: 10.1038/s41590-018-0068-4. Epub 2018 Mar 19.
Recognition of microbial viability via TLR8 drives TFH cell differentiation and vaccine responses.
Ugolini M, Gerhard J, Burkert S, Jensen KJ, Georg P, Ebner F, Volkers SM, Thada S, Dietert K, Bauer L, Schäfer A, Helbig ET, Opitz B, Kurth F, Sur S, Dittrich, Gaddam S, Conrad ML, Benn CS, Blohm U, Gruber AD, Hutloff A, Hartmann S, Boekschoten MV, Müller M14,15, Jungersen G, Schumann RR, Suttorp N, Sander LE.

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Monday, March. 26th, 2018 - Anna Wenning

Cell. 2018 Feb 8;172(4):784-796.e18. doi: 10.1016/j.cell.2017.12.033. Epub 2018 Jan 18.
Non-classical Immunity Controls Microbiota Impact on Skin Immunity and Tissue Repair.
Linehan JL, Harrison OJ, Han SJ, Byrd AL, Vujkovic-Cvijin I, Villarino AV, Sen SK, Shaik J, Smelkinson M, Tamoutounour S, Collins N, Bouladoux N, Dzutsev A, Rosshart SP, Arbuckle JH, Wang CR, Kristie TM, Rehermann B, Trinchieri G, Brenchley JM, O'Shea JJ, Belkaid Y.

PubMed Link

Microbiome. 2018 Jan 30;6(1):20. doi: 10.1186/s40168-018-0404-9.
Commensal microbiota modulate gene expression in the skin.
Meisel JS, Sfyroera G, Bartow-McKenney C, Gimblet C, Bugayev J, Horwinski J, Kim B, Brestoff JR, Tyldsley AS, Zheng Q, Hodkinson BP, Artis D, Grice EA.

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Monday, March. 5th, 2018 - Marcel Sorribas

Ann Hepatol. 2018 Mar 1;17(2):318-329. doi: 10.5604/01.3001.0010.8662.
Bacterial Translocation Is Linked to Increased Intestinal IFN-γ, IL-4, IL-17, and mucin-2 in Cholestatic Rats.
Vega-Magaña N, Delgado-Rizo V, García-Benavides L, Del Toro-Arreola S, Segura-Ortega J, Morales ASMZ, Zepeda-Nuño JS, Escarra-Senmarti M, Gutiérrez-Franco J, Haramati J, Bueno-Topete MR.

PubMed Link

Gastroenterology. 2018 Jun;154(8):2178-2193. doi: 10.1053/j.gastro.2018.02.019. Epub 2018 Feb 15.
Alterations in Intestinal Microbiota Lead to Production of Interleukin 17 by Intrahepatic γδ T-Cell Receptor-Positive Cells and Pathogenesis of Cholestatic Liver Disease.
Tedesco D, Thapa M, Chin CY, Ge Y, Gong M, Li J, Gumber S, Speck P, Elrod EJ, Burd EM, Kitchens WH, Magliocca JF, Adams AB, Weiss DS, Mohamadzadeh M, Grakoui A.

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Friday, Feb. 23th, 2018 - Mercedes Gomez

Nature. 2018 Feb 15;554(7692):373-377. doi: 10.1038/nature25500. Epub 2018 Feb 7.
c-MAF-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont.
Xu M, Pokrovskii M, Ding Y, Yi R, Au C, Harrison OJ, Galan C, Belkaid Y, Bonneau R, Littman DR.

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Nature. 2018 Feb 8;554(7691):255-259. doi: 10.1038/nature25437. Epub 2018 Jan 22.
Innate and adaptive lymphocytes sequentially shape the gut microbiota and lipid metabolism.
Mao K, Baptista AP, Tamoutounour S, Zhuang L, Bouladoux N, Martins AJ, Huang Y, Gerner MY, Belkaid Y, Germain RN.

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Monday, Feb. 5th, 2018 - Julien

Nat Microbiol. 2018 Mar;3(3):347-355. doi: 10.1038/s41564-017-0096-0. Epub 2018 Jan 15.
Stability of the human faecal microbiome in a cohort of adult men.
Mehta RS, Abu-Ali GS, Drew DA, Lloyd-Price J, Subramanian A, Lochhead P, Joshi AD, Ivey KL, Khalili H, Brown GT, DuLong C, Song M, Nguyen LH, Mallick H, Rimm EB, Izard J, Huttenhower C, Chan AT.

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Nature. 2018 Jan 11;553(7687):208-211. doi: 10.1038/nature25172. Epub 2018 Jan 3.
Precision editing of the gut microbiota ameliorates colitis.
Zhu W, Winter MG, Byndloss MX, Spiga L, Duerkop BA, Hughes ER, Büttner L, de Lima Romão E, Behrendt CL, Lopez CA, Sifuentes-Dominguez L, Huff-Hardy K, Wilson RP, Gillis CC, Tükel Ç, Koh AY,, Burstein E, Hooper LV, Bäumler AJ, Winter SE.

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