Journal Club 2016



 

Friday, Nov. 19th, 2016 - Jakob Zimmermann (Paper Summary)

Cell. 2016 Nov 3;167(4):1067-1078.e16. doi: 10.1016/j.cell.2016.09.050. Epub 2016 Oct 20.
Regulatory T Cell Specificity Directs Tolerance versus Allergy against Aeroantigens in Humans.
Bacher P, Heinrich F, Stervbo U, Nienen M, Vahldieck M, Iwert C, Vogt K, Kollet J, Babel N, Sawitzki B, Schwarz C, Bereswill S, Heimesaat MM, Heine G, Gadermaier G, Asam C, Assenmacher M, Kniemeyer O, Brakhage AA, Ferreira F, Wallner M, Worm M, Scheffold A.

PubMed Link

Cell. 2016 Nov 3;167(4):1125-1136.e8. doi: 10.1016/j.cell.2016.10.020.
Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity.
Schirmer M, Smeekens SP, Vlamakis H, Jaeger M, Oosting M, Franzosa EA, Jansen T, Jacobs L, Bonder MJ, Kurilshikov A, Fu J, Joosten LA, Zhernakova A, Huttenhower C, Wijmenga C, Netea MG, Xavier RJ.

PubMed Link


Monday, Nov. 14th, 2016 - Catherine Mooser (Paper Summary)

Cell. 2016 Jun 16;165(7):1708-20. doi: 10.1016/j.cell.2016.05.018. Epub 2016 Jun 2.
The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites.
Kaiko GE, Ryu SH, Koues OI, Collins PL, Solnica-Krezel L, Pearce EJ, Pearce EL, Oltz EM, Stappenbeck TS.

PubMed Link

Immunity. 2016 Apr 19;44(4):875-88. doi: 10.1016/j.immuni.2016.03.013.
Gut Microbiota Drive Autoimmune Arthritis by Promoting Differentiation and Migration of Peyer's Patch T Follicular Helper Cells.
Teng F, Klinger CN, Felix KM, Bradley CP, Wu E, Tran NL, Umesaki Y, Wu HJ.

PubMed Link


Friday, Nov. 11th, 2016 - Marcel Sorribas (Paper Summary)

Sci Rep. 2016 Sep 16;6:33453. doi: 10.1038/srep33453.
FXR agonist obeticholic acid reduces hepatic inflammation and fibrosis in a rat model of toxic cirrhosis.
Verbeke L, Mannaerts I, Schierwagen R, Govaere O, Klein S, Vander Elst I, Windmolders P, Farre R, Wenes M, Mazzone M, Nevens F, van Grunsven LA, Trebicka J, Laleman W.

PubMed Link

J Hepatol. 2016 May;64(5):1049-57. doi: 10.1016/j.jhep.2015.12.010. Epub 2015 Dec 23.
Obeticholic acid reduces bacterial translocation and inhibits intestinal inflammation in cirrhotic rats.
Úbeda M, Lario M, Muñoz L, Borrero MJ, Rodríguez-Serrano M, Sánchez-Díaz AM, del Campo R, Lledó L, Pastor Ó, García-Bermejo L, Díaz D, Álvarez-Mon M, Albillos A.

PubMed Link


Monday, Nov. 7th, 2016 - Francesca Ronchi (Paper Summary)

Cell. 2016 Oct 6;167(2):444-456.e14. doi: 10.1016/j.cell.2016.08.076.
Host-Protozoan Interactions Protect from Mucosal Infections through Activation of the Inflammasome.
Chudnovskiy A, Mortha A, Kana V, Kennard A, Ramirez JD, Rahman A, Remark R, Mogno I, Ng R, Gnjatic S, Amir ED, Solovyov A, Greenbaum B, Clemente J, Faith J, Belkaid Y, Grigg ME, Merad M.

PubMed Link

Cell Host Microbe. 2016 Oct 12;20(4):515-526. doi: 10.1016/j.chom.2016.09.001. Epub 2016 Sep 29.
Stable Engraftment of Bifidobacterium longum AH1206 in the Human Gut Depends on Individualized Features of the Resident Microbiome.
Maldonado-Gómez MX, Martínez I, Bottacini F, O'Callaghan A, Ventura M, van Sinderen D, Hillmann B, Vangay P, Knights D, Hutkins RW, Walter J.

PubMed Link


Monday, Oct. 31st, 2016 - Miguelangel Cuenca (Paper Summary)

PLoS One. 2016 Jul 20;11(7):e0159676. doi: 10.1371/journal.pone.0159676. eCollection 2016.
Nutrient Deprivation Affects Salmonella Invasion and Its Interaction with the Gastrointestinal Microbiota.
Yurist-Doutsch S, Arrieta MC, Tupin A, Valdez Y, Antunes LC, Yen R, Finlay BB.

PubMed Link

MBio. 2014 Jul 29;5(4):e01183-14. doi: 10.1128/mBio.01183-14.
Antivirulence activity of the human gut metabolome.
Antunes LC, McDonald JA, Schroeter K, Carlucci C, Ferreira RB, Wang M, Yurist-Doutsch S, Hira G, Jacobson K, Davies J, Allen-Vercoe E, Finlay BB.

PubMed Link


Friday, Oct. 21st, 2016 - Nicolas Studer  (Paper Summary)

Nat Microbiol. 2016 Jul 11;1(8):16108. doi: 10.1038/nmicrobiol.2016.108.
The binary toxin CDT enhances Clostridium difficile virulence by suppressing protective colonic eosinophilia.
Cowardin CA, Buonomo EL, Saleh MM, Wilson MG, Burgess SL, Kuehne SA, Schwan C, Eichhoff AM, Koch-Nolte F, Lyras D, Aktories K, Minton NP, Petri WA Jr.

PubMed Link

Nat Med. 2016 Nov;22(11):1330-1334. doi: 10.1038/nm.4174. Epub 2016 Sep 26.
Dietary zinc alters the microbiota and decreases resistance to Clostridium difficile infection.
Zackular JP, Moore JL, Jordan AT, Juttukonda LJ, Noto MJ, Nicholson MR, Crews JD, Semler MW, Zhang Y, Ware LB,4, Washington MK, Chazin WJ, Caprioli RM, Skaar EP.

PubMed Link


Monday, Sep. 26th, 2016 - Stefanie Buschor  (Paper Summary)

Science. 2016 Sep 16;353(6305):1249-53. doi: 10.1126/science.aag3042. Epub 2016 Sep 15.
Virulence factors enhance Citrobacter rodentium expansion through aerobic respiration.
Lopez CA, Miller BM, Rivera-Chávez F, Velazquez EM, Byndloss MX, Chávez-Arroyo A, Lokken KL, Tsolis RM, Winter SE, Bäumler AJ.

PubMed Link

Mucosal Immunol. 2016 Sep 14. doi: 10.1038/mi.2016.77. [Epub ahead of print]
Bacterial virulence factor inhibits caspase-4/11 activation in intestinal epithelial cells.
Pallett MA1, Crepin VF1, Serafini N2,3, Habibzay M1, Kotik O1, Sanchez-Garrido J4, Di Santo JP2,3, Shenoy AR4, Berger CN1, Frankel G1.

PubMed Link


Friday, Sep. 16th, 2016 - Stephanie Ganal-Vonarburg (Paper Summary)

Cell. 2016 Aug 25;166(5):1231-1246.e13. doi: 10.1016/j.cell.2016.07.043. Epub 2016 Aug 18.
The Spectrum and Regulatory Landscape of Intestinal Innate Lymphoid Cells Are Shaped by the Microbiome.
Gury-BenAri M, Thaiss CA, Serafini N, Winter DR, Giladi A, Lara-Astiaso D, Levy M, Salame TM, Weiner A, David E, Shapiro H, Dori-Bachash M, Pevsner-Fischer M, Lorenzo-Vivas E, Keren-Shaul H, Paul F, Harmelin A, Eberl G, Itzkovitz S, Tanay A, Di Santo JP, Elinav E, Amit I.

PubMed Link

Nature Microbiology, 2016. ARTICLE NUMBER: 16140 | DOI: 10.1038/NMICROBIOL.2016.140
Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice
Alexandra E. Livanos, Thomas U. Greiner, Pajau Vangay, Wimal Pathmasiri, Delisha Stewart, Susan McRitchie, Huilin Li, Jennifer Chung, Jiho Sohn, Sara Kim, Zhan Gao, Cecily Barber, Joanne Kim, Sandy Ng, Arlin B. Rogers, Susan Sumner, Xue-Song Zhang, Ken Cadwell, Dan Knights, Alexander Alekseyenko, Fredrik Bäckhed & Martin J. Blaser
PubMed Link


Friday, Sep. 12th, 2016 - Julien Limenitakis (Paper Summary)

Nat Microbiol. 2016 ARTICLE NUMBER: 16152 | DOI: 10.1038/NMICROBIOL.2016.152
Transcriptional interactions suggest niche segregation among microorganisms in the human gut. 
Damian Rafal Plichta, Agnieszka Sierakowska Juncker, Marcelo Bertalan, Elizabeth Rettedal, Laurent Gautier, Encarna Varela, Chaysavanh Manichanh5, Charlène Fouqueray, Florence Levenez, Trine Nielsen, Joël Doré, Ana Manuel Dantas Machado, Mari Cristina Rodriguez de Evgrafov, Torben Hansen, Torben Jørgensen, Peer Bork, Francisco Guarner, Oluf Pedersen, Metagenomics of the Human Intestinal Tract (MetaHIT) Consortium†, Morten O. A. Sommer, S. Dusko Ehrlich, Thomas Sicheritz-Pontén, Søren Brunak and H. Bjørn Nielsen
PubMed Link

Nat Microbiol. 2016 Jul 4;1(9):16103. doi: 10.1038/nmicrobiol.2016.103.
Interplay between microbial D-amino acids and host D-amino acid oxidase modifies murine mucosal defence and gut microbiota.
Jumpei Sasabe, Yurika Miyoshi, Seth Rakoff-Nahoum, Ting Zhang, MasashiMita, Brigid M. Davis, Kenji Hamase and Matthew K. Waldor
PubMed Link


Friday, Sep. 5th, 2016 - Hai Li (Paper Summary)

Nature. 2016 Jun 8;534(7606):213-7. doi: 10.1038/nature18309.
Acetate mediates a microbiome-brain-β-cell axis to promote metabolic syndrome.
Perry RJ, Peng L, Barry NA, Cline GW, Zhang D, Cardone RL, Petersen KF, Kibbey RG, Goodman AL, Shulman GI.

PubMed Link

Nat Microbiol. 2016 Jul 4;1(9):16103. doi: 10.1038/nmicrobiol.2016.103.
High-affinity monoclonal IgA regulates gut microbiota and prevents colitis in mice.
Okai S, Usui F, Yokota S, Hori-I Y, Hasegawa M, Nakamura T, Kurosawa M, Okada S, Yamamoto K, Nishiyama E, Mori H, Yamada T, Kurokawa K, Matsumoto S, Nanno M, Naito T, Watanabe Y, Kato T, Miyauchi E, Ohno H, Shinkura R.

PubMed Link


Friday, Aug. 22nd, 2016 - Bahti YILMAZ (Paper Summary)

Cell Host Microbe. 2016 Aug 10;20(2):202-14. doi: 10.1016/j.chom.2016.07.001. Epub 2016 Jul 28.
Gut Microbial Metabolites Fuel Host Antibody Responses.
Kim M, Qie Y, Park J, Kim CH.

PubMed Link

Nat Microbiol. 2016 Jun 27;1(9):16093. doi: 10.1038/nmicrobiol.2016.93.
Colonic transit time is related to bacterial metabolism and mucosal turnover in the gut.
Roager HM, Hansen LB, Bahl MI, Frandsen HL, Carvalho V, Gøbel RJ, Dalgaard MD, Plichta DR, Sparholt MH, Vestergaard H, Hansen T, Sicheritz-Pontén T, Nielsen HB, Pedersen O, Lauritzen L, Kristensen M, Gupta R, Licht TR.

PubMed Link


Friday, Aug. 15th, 2016 - Stephanie Uster (Paper Summary)

Immunity. 2016 Mar 15;44(3):634-46. doi: 10.1016/j.immuni.2016.02.019.
Lymphoid-Tissue-Resident Commensal Bacteria Promote Members of the IL-10 Cytokine Family to Establish Mutualism.
Fung TC, Bessman NJ, Hepworth MR, Kumar N, Shibata N, Kobuley D, Wang K, Ziegler CG, Goc J, Shima T, Umesaki Y, Sartor RB, Sullivan KV, Lawley TD, Kunisawa J, Kiyono H, Sonnenberg GF.

PubMed Link

Immunity. 2015 Aug 18;43(2):343-53. doi: 10.1016/j.immuni.2015.07.014.
Microbiota-Dependent Activation of an Autoreactive T Cell Receptor Provokes Autoimmunity in an Immunologically Privileged Site.
Horai R, Zárate-Bladés CR, Dillenburg-Pilla P, Chen J, Kielczewski JL, Silver PB, Jittayasothorn Y, Chan CC, Yamane H, Honda K, Caspi RR.

PubMed Link


Friday, July 8th, 2016 - Mercedes Gomez

Gastroenterology. 2016 Aug;151(2):311-23. doi: 10.1053/j.gastro.2016.04.014. Epub 2016 Apr 27.
Mouse and Human Liver Contain Immunoglobulin A-Secreting Cells Originating From Peyer's Patches and Directed Against Intestinal Antigens.
Moro-Sibilot L, Blanc P, Taillardet M, Bardel E, Couillault C, Boschetti G, Traverse-Glehen A, Defrance T, Kaiserlian D, Dubois B.

PubMed Link

Nat Med. 2016 Jun;22(6):598-605. doi: 10.1038/nm.4102. Epub 2016 May 9.
CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands.
Lamas B, Richard ML, Leducq V, Pham HP, Michel ML, Da Costa G, Bridonneau C, Jegou S, Hoffmann TW, Natividad JM, Brot L, Taleb S, Couturier-Maillard A, Nion-Larmurier I, Merabtene F, Seksik P, Bourrier A, Cosnes J, Ryffel B, Beaugerie L, Launay JM, Langella P, Xavier RJ, Sokol H.

PubMed Link 


Friday, June 17th, 2016 - Francesca Ronchi (download presentation file)

Nature. 2016 Apr 28;532(7600):512-6. doi: 10.1038/nature17655. Epub 2016 Apr 20.
Normalizing the environment recapitulates adult human immune traits in laboratory mice.
Beura LK, Hamilton SE, Bi K, Schenkel JM, Odumade OA, Casey KA, Thompson EA, Fraser KA, Rosato PC, Filali-Mouhim A, Sekaly RP, Jenkins MK, Vezys V, Haining WN, Jameson SC, Masopust D

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Science. 2016 Jun 2. pii: aaf3892. [Epub ahead of print]
Tissue adaptation of regulatory and intraepithelial CD4+ T cells controls gut inflammation.
Sujino T, London M, Hoytema van Konijnenburg DP, Rendon T, Buch T, Silva HM, Lafaille JJ, Reis BS, Mucida D

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Friday, June 2nd, 2016 - Li Hai (download presentation file)

Cell Host Microbe. 2016 May 11;19(5):651-63. doi: 10.1016/j.chom.2016.04.007.
Defensive Mutualism Rescues NADPH Oxidase Inactivation in Gut Infection.
Pircalabioru G, Aviello G, Kubica M, Zhdanov A, Paclet MH, Brennan L, Hertzberger R, Papkovsky D, Bourke B, Knaus UG

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AOP Nature, 1–15. http://doi.org/10.1038/nature17940; (2016)
Development of the gut microbiota and mucosal IgA responses in twins and gnotobiotic mice.
Planer, J. D., Peng, Y., Kau, A. L., Blanton, L. V., Ndao, I. M., Tarr, P. I., Warner, B.B., Gordon, JI

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Friday, May 27th, 2016 - Catherine Mooser (download presentation file)

Cell Host Microbe. 2016 May 11;19(5):651-63. doi: 10.1016/j.chom.2016.04.007.
Defensive Mutualism Rescues NADPH Oxidase Inactivation in Gut Infection.
Pircalabioru G, Aviello G, Kubica M, Zhdanov A, Paclet MH, Brennan L, Hertzberger R, Papkovsky D, Bourke B, Knaus UG

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Science. 2016 May 13;352(6287):aaf4822. doi: 10.1126/science.aaf4822.
IgA production requires B cell interaction with subepithelial dendritic cells in Peyer's patches.
Reboldi A, Arnon TI, Rodda LB, Atakilit A, Sheppard D, Cyster JG

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Friday, May 20th, 2016 - Bahti Yilmaz (download presentation file)

Science, 1–10. http://doi.org/10.1126/science.aad9948 (2016).
Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease.
Chu, H., Khosravi, A., Kusumawardhani, I. P., Kwon, A. H. K., Vasconcelos, A. C., Cunha, L. D., et al.  

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Cell. 2016 May 5;165(4):827-41. doi: 10.1016/j.cell.2016.04.055.
Maternal IgG and IgA Antibodies Dampen Mucosal T Helper Cell Responses in Early Life.
Koch MA, Reiner GL, Lugo KA, Kreuk LS, Stanbery AG, Ansaldo E, Seher TD, Ludington WB, Barton GM

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Friday, April 29th, 2016 - Marcel Sorribas (download presentation file)

Clin Res Hepatol Gastroenterol. 2016 Apr 6. pii: S2210-7401(16)30038-9. doi: 10.1016/j.clinre.2016.02.008. [Epub ahead of print]
Changes in gut toll-like receptor-4 and nod-like receptor family pyrin domain containing-3 innate pathways in liver cirrhosis rats with bacterial translocation.
Liu L, Zhang C, Hu Y, Zhou L, Tan Q

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Cell Host Microbe. 2016 Feb 10;19(2):227-39. doi: 10.1016/j.chom.2016.01.003.
Intestinal REG3 Lectins Protect against Alcoholic Steatohepatitis by Reducing Mucosa-Associated Microbiota and Preventing Bacterial Translocation.
Wang L, Fouts DE, Stärkel P, Hartmann P, Chen P, Llorente C, DePew J, Moncera K, Ho SB, Brenner DA, Hooper LV, Schnabl B

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Friday, April 22nd, 2016 - Stephanie Ganal (download presentation file)

Cell Host Microbe. 2016 Apr 13;19(4):443-54. doi: 10.1016/j.chom.2016.03.004.
Depletion of Butyrate-Producing Clostridia from the Gut Microbiota Drives an Aerobic Luminal Expansion of Salmonella.
Rivera-Chávez F, Zhang LF, Faber F, Lopez CA, Byndloss MX, Olsan EE, Xu G, Velazquez EM, Lebrilla CB, Winter SE, Bäumler AJ

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Immunity. 2016 Apr 19;44(4):889-900. doi: 10.1016/j.immuni.2016.03.009. Epub 2016 Apr 12.
Enteric Viruses Ameliorate Gut Inflammation via Toll-like Receptor 3 and Toll-like Receptor 7-Mediated Interferon-β Production.
Yang JY, Kim MS, Kim E, Cheon JH, Lee YS, Kim Y, Lee SH, Seo SU, Shin SH, Choi SS, Kim B, Chang SY, Ko HJ, Bae JW, Kweon MN

PubMed Link  PDF + Suppl. (password)


Friday, date to be announced, 2016 - Yasu Uchimura (download presentation file)

Cell. 2016 Jan 28;164(3):378-91. doi: 10.1016/j.cell.2015.12.023.
Neuro-immune Interactions Drive Tissue Programming in Intestinal Macrophages.
Gabanyi I, Muller PA, Feighery L, Oliveira TY, Costa-Pinto FA, Mucida D

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Science. 2016 Apr 1;352(6281):aac7341. doi: 10.1126/science.aac7341.
Genetic circuit design automation.
Nielsen AA, Der BS, Shin J, Vaidyanathan P, Paralanov V, Strychalski EA, Ross D, Densmore D, Voigt CA

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Science. 2016 Mar 25;351(6280):aad6253. doi: 10.1126/science.aad6253.
Design and synthesis of a minimal bacterial genome.
Hutchison CA 3rd, Chuang RY, Noskov VN, Assad-Garcia N, Deerinck TJ, Ellisman MH, Gill J, Kannan K, Karas BJ, Ma L, Pelletier JF, Qi ZQ, Richter RA, Strychalski EA, Sun L, Suzuki Y, Tsvetanova B, Wise KS, Smith HO, Glass JI, Merryman C, Gibson DG, Venter JC

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Friday, April 8th, 2016 - Julien Limenitakis (download presentation file)

PLoS Genet. 2016 Feb 12;12(2):e1005861. doi: 10.1371/journal.pgen.1005861. eCollection 2016.
Carriage of λ Latent Virus Is Costly for Its Bacterial Host due to Frequent Reactivation in Monoxenic Mouse Intestine.
De Paepe M, Tournier L, Moncaut E, Son O, Langella P, Petit MA

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Cell Host Microbe. 2016 Mar 22. pii: S1931-3128(16)30062-2. doi: 10.1016/j.chom.2016.02.021.
Host Selection of Microbiota via Differential Adhesion.
McLoughlin K, Schluter J, Rakoff-Nahoum S, Smith AL, Foster KR

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Friday, March 18th, 2016 - Mercedes Gomez (download presentation file)

Nat Med. 2016 Mar;22(3):319-23. doi: 10.1038/nm.4046. Epub 2016 Feb 15.
Transient inhibition of ROR-γt therapeutically limits intestinal inflammation by reducing TH17 cells and preserving group 3 innate lymphoid cells.
Withers DR, Hepworth MR, Wang X, Mackley EC, Halford EE, Dutton EE, Marriott CL, Brucklacher-Waldert V, Veldhoen M, Kelsen J, Baldassano RN, Sonnenberg GF

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Nat Med. 2016 Mar;22(3):250-3. doi: 10.1038/nm.4039. Epub 2016 Feb 1.
Partial restoration of the microbiota of cesarean-born infants via vaginal microbial transfer.
Dominguez-Bello MG, De Jesus-Laboy KM, Shen N, Cox LM, Amir A, Gonzalez A, Bokulich NA, Song SJ, Hoashi M, Rivera-Vinas JI, Mendez K, Knight R, Clemente JC

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Friday, March 11th, 2016 - Li Hai (download presentation file)

Nature. 2016 Mar 3;531(7592):53-8. doi: 10.1038/nature17173.
High-fat diet enhances stemness and tumorigenicity of intestinal progenitors.
Beyaz S, Mana MD, Roper J, Kedrin D, Saadatpour A, Hong SJ, Bauer-Rowe KE, Xifaras ME, Akkad A, Arias E, Pinello L, Katz Y, Shinagare S, Abu-Remaileh M, Mihaylova MM, Lamming DW, Dogum R, Guo G, Bell GW, Selig M, Nielsen GP, Gupta N, Ferrone CR, Deshpande V, Yuan GC, Orkin SH, Sabatini DM, Yilmaz ÖH

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Immunity. 2016 Feb 29. pii: S1074-7613(16)30021-8. doi: 10.1016/j.immuni.2016.02.006. [Epub ahead of print]
Gut Microbiota-Induced Immunoglobulin G Controls Systemic Infection by Symbiotic Bacteria and Pathogens.
Zeng MY, Cisalpino D, Varadarajan S, Hellman J, Warren HS, Cascalho M, Inohara N, Núñez G6

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Friday, February 26th, 2016 - Yasmin Köller (download presentation file)

Cell. 2016 Feb 17. pii: S0092-8674(16)30001-0. doi: 10.1016/j.cell.2016.01.024. [Epub ahead of print]
Sialylated Milk Oligosaccharides Promote Microbiota-Dependent Growth in Models of Infant Undernutrition.
Charbonneau MR, O'Donnell D, Blanton LV, Totten SM, Davis JC, Barratt MJ, Cheng J, Guruge J, Talcott M, Bain JR, Muehlbauer MJ, Ilkayeva O, Wu C, Struckmeyer T, Barile D, Mangani C, Jorgensen J, Fan YM, Maleta K, Dewey K, Ashorn P, Newgard CB, Lebrilla C, Mills DA, Gordon JI

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Science. 2016 Feb 19;351(6275). pii: aad3311. doi: 10.1126/science.aad3311.
Gut bacteria that prevent growth impairments transmitted by microbiota from malnourished children.
Blanton LV, Charbonneau MR, Salih T, Barratt MJ, Venkatesh S, Ilkaveya O, Subramanian S, Manary MJ, Trehan I, Jorgensen JM, Fan YM, Henrissat B, Leyn SA, Rodionov DA, Osterman AL, Maleta KM, Newgard CB, Ashorn P, Dewey KG, Gordon JI

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Friday, February 19th, 2016 - Sandra Rupp (download presentation file)

Science. 2016 Jan 28. pii: aad0314. [Epub ahead of print]
The maternal interleukin-17a pathway in mice promotes autismlike phenotypes in offspring.
Choi GB, Yim YS, Wong H, Kim S, Kim H, Kim SV, Hoeffer CA, Littman DR, Huh JR

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Mucosal Immunol. 2016 Jan;9(1):83-97. doi: 10.1038/mi.2015.38.
Long-lived plasma cells are generated in mucosal immune responses and contribute to the bone marrow plasma cell pool in mice.
Lemke A, Kraft M, Roth K, Riedel R, Lammerding D, Hauser AE

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Friday, February 12th, 2016 - Francesca Ronchi (download presentation file)

Science. 2016 Feb 4. pii: aaf1648. [Epub ahead of print]
Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut.
Howitt MR, Lavoie S, Michaud M, Blum AM, Tran SV, Weinstock JV, Gallini CA, Redding K, Margolskee RF, Osborne LC, Artis D,Garrett WS

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Science. 2016 Jan 28. pii: aac5560. [Epub ahead of print]
Dietary antigens limit mucosal immunity by inducing regulatory T cells in the small intestine.
Kim KS, Hong SW, Han D, Yi J, Jung J, Yang BG, Lee JY, Lee M, Surh CD

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Friday, January 29th, 2016 - Catherine Mooser (download presentation file)

Nature. 2016 Jan 14;529(7585):212-5. doi: 10.1038/nature16504.
Diet-induced extinctions in the gut microbiota compound over generations.
Sonnenburg ED, Smits SA, Tikhonov M, Higginbottom SK, Wingreen NS, Sonnenburg JL

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Nat Med. 2015 Dec;21(12):1497-501. doi: 10.1038/nm.3994. Epub 2015 Nov 16.
Microbiota depletion promotes browning of white adipose tissue and reduces obesity.
Suárez-Zamorano N, Fabbiano S, Chevalier C, Stojanović O, Colin D, Stevanović A, Veyrat-Durebex C, Tarallo V, Rigo D, Germain S, Ilievska M, Montet X, Seimbille Y, Hapfelmeier S, Trajkovski M

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Friday, January 8th, 2016 - Stephanie Ganal (download presentation file)

Science. 2015 Nov 20;350(6263):981-5. doi: 10.1126/science.aac9593. Epub 2015 Oct 15.
Tissue residency of innate lymphoid cells in lymphoid and nonlymphoid organs.
Gasteiger G, Fan X, Dikiy S, Lee SY, Rudensky AY

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Nature. 2015 Dec 24;528(7583):560-4. doi: 10.1038/nature16460. Epub 2015 Dec 9.
Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration.
Lindemans CA, Calafiore M, Mertelsmann AM, O'Connor MH, Dudakov JA, Jenq RR, Velardi E, Young LF, Smith OM, Lawrence G, Ivanov JA, Fu YY, Takashima S, Hua G, Martin ML, O'Rourke KP, Lo YH, Mokry M, Romera-Hernandez M, Cupedo T, Dow LE, Nieuwenhuis EE, Shroyer NF, Liu C, Kolesnick R, van den Brink MR, Hanash AM

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