Journal Club 2015



Monday, Dec. 14th, 2015 - Marcel (download presentation file)

Cell. 2015 Dec 3;163(6):1428-43. doi: 10.1016/j.cell.2015.10.048.
Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling.
Levy M, Thaiss CA, Zeevi D, Dohnalová L, Zilberman-Schapira G, Mahdi JA, David E, Savidor A, Korem T, Herzig Y, Pevsner-Fischer M, Shapiro H, Christ A, Harmelin A, Halpern Z, Latz E, Flavell RA, Amit I, Segal E, Elinav E.

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Cell. 2015 Dec 3;163(6):1444-56. doi: 10.1016/j.cell.2015.10.072.
Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis.
Nowarski R, Jackson R, Gagliani N, de Zoete MR, Palm NW, Bailis W, Low JS, Harman CC, Graham M, Elinav E, Flavell RA.

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Friday, Dec. 11th, 2015 - Madeleine (download presentation file)

Cell. 2015 Sep 24;163(1):95-107. doi: 10.1016/j.cell.2015.08.059.
Regulators of gut motility revealed by a gnotobiotic model of diet-microbiome interactions related to travel.
Dey N, Wagner VE, Blanton LV, Cheng J, Fontana L, Haque R, Ahmed T, Gordon JI.

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Nat Med. 2015 Oct;21(10):1228-34. doi: 10.1038/nm.3950. Epub 2015 Sep 14.
Early life dynamics of the human gut virome and bacterial microbiome in infants.
Lim ES, Zhou Y, Zhao G, Bauer IK, Droit L, Ndao IM, Warner BB, Tarr PI, Wang D, Holtz LR.

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Friday, Dec. 4th, 2015 - Bahti (download presentation file)

Cell. 2015 Nov 19;163(5):1079-94. doi: 10.1016/j.cell.2015.11.001.
Personalized Nutrition by Prediction of Glycemic Responses.
Zeevi D, Korem T, Zmora N, Israeli D, Rothschild D, Weinberger A, Ben-Yacov O, Lador D, Avnit-Sagi T, Lotan-Pompan M, Suez J, Mahdi JA, Matot E, Malka G, Kosower N, Rein M, Zilberman-Schapira G, Dohnalová L, Pevsner-Fischer M, Bikovsky R, Halpern Z, Elinav E, Segal E.

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Cell Host Microbe. 2015 Oct 14;18(4):489-500. doi: 10.1016/j.chom.2015.09.008.
Inflammation, Antibiotics, and Diet as Environmental Stressors of the Gut Microbiome in Pediatric Crohn's Disease.
Lewis JD, Chen EZ, Baldassano RN, Otley AR, Griffiths AM, Lee D, Bittinger K, Bailey A, Friedman ES, Hoffmann C, Albenberg L, Sinha R, Compher C, Gilroy E, Nessel L, Grant A, Chehoud C, Li H, Wu GD, Bushman FD.

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Friday, Nov. 27th, 2015 - Yasu (download presentation file)

Nature. 2015 Sep 10;525(7568):251-5. doi: 10.1038/nature14966. Epub 2015 Aug 19.
Single-cell messenger RNA sequencing reveals rare intestinal cell types.
Grün D, Lyubimova A1, Kester L, Wiebrands K, Basak O, Sasaki N, Clevers H, van Oudenaarden A

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Cell. 2015 Apr 9;161(2):264-76. doi: 10.1016/j.cell.2015.02.047.
Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis.
Yano JM, Yu K, Donaldson GP, Shastri GG, Ann P, Ma L, Nagler CR, Ismagilov RF, Mazmanian SK, Hsiao EY.

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Friday, Nov. 20th, 2015 - Mercedes (download presentation file)

Cell Host Microbe. 2015 Nov 11;18(5):582-92. doi: 10.1016/j.chom.2015.10.007. Epub 2015 Oct 29.
Normalization of Host Intestinal Mucus Layers Requires Long-Term Microbial Colonization.
Johansson ME, Jakobsson HE, Holmén-Larsson J, Schütte A, Ermund A, Rodríguez-Piñeiro AM, Arike L, Wising C, Svensson F, Bäckhed F, Hansson GC.

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Immunity. 2015 Oct 20;43(4):817-29. doi: 10.1016/j.immuni.2015.09.007.
Dietary Fatty Acids Directly Impact Central Nervous System Autoimmunity via the Small Intestine.
Haghikia A, Jörg S, Duscha A, Berg J, Manzel A, Waschbisch A, Hammer A, Lee DH, May C, Wilck N, Balogh A, Ostermann AI, Schebb NH, Akkad DA, Grohme DA, Kleinewietfeld M, Kempa S, Thöne J, Demir S, Müller DN, Gold R, Linker RA.

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Monday, Nov. 16th, 2015 - Anna (download presentation file)

Nat Commun. 2015 Oct 23;6:8642. doi: 10.1038/ncomms9642.
MHC variation sculpts individualized microbial communities that control susceptibility to enteric infection.
Kubinak JL, Stephens WZ, Soto R, Petersen C, Chiaro T, Gogokhia L, Bell R, Ajami NJ, Petrosino JF, Morrison L, Potts WK, Jensen PE, O'Connell RM, Round JL.

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Immunity. 2015 Sep 15;43(3):527-40. doi: 10.1016/j.immuni.2015.08.011. Epub 2015 Sep 8.
BALB/c and C57BL/6 Mice Differ in Polyreactive IgA Abundance, which Impacts the Generation of Antigen-Specific IgA and Microbiota Diversity.
Fransen F, Zagato E, Mazzini E, Fosso B, Manzari C, El Aidy S, Chiavelli A, D'Erchia AM, Sethi MK, Pabst O, Marzano M, Moretti S, Romani L, Penna G, Pesole G, Rescigno M.

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Friday, October 30th, 2015 - Li Hai (download presentation file)

Nature. 2015 Oct 29;526(7575):719-22. doi: 10.1038/nature15524. Epub 2015 Oct 19.
Bacteriocin production augments niche competition by enterococci in the mammalian gastrointestinal tract.
Kommineni S, Bretl D, Lam , Chakraborty R, Hayward M, Simpson P, Cao Y, Bousounis P, Kristich C, Salzman NH.

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Cell Host Microbe. 2015 Oct 14;18(4):478-88. doi: 10.1016/j.chom.2015.09.002. Epub 2015 Oct 1.
Quantitative Imaging of Gut Microbiota Spatial Organization.
Earle KA, Billings G, Sigal M, Lichtman JS, Hansson GC, Elias JE, Amieva MR, Huang KC, Sonnenburg JL.

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Friday, October 16th, 2015 - Francesca (download presentation file)

Cell. 2015 Oct 8;163(2):381-93. doi: 10.1016/j.cell.2015.08.061. Epub 2015 Sep 24.
An IL-23R/IL-22 Circuit Regulates Epithelial Serum Amyloid A to Promote Local Effector Th17 Responses.
Sano T, Huang W, Hall JA, Yang Y, Chen A, Gavzy SJ, Lee JY, Ziel JW, Miraldi ER, Domingos AI, Bonneau R, Littman DR.

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Immunity. 2015 Feb 17;42(2):321-31. doi: 10.1016/j.immuni.2015.01.011. Epub 2015 Feb 10.
Interleukin-22 induces interleukin-18 expression from epithelial cells during intestinal infection.
Muñoz M, Eidenschenk C, Ota N, Wong K, Lohmann U, Kühl AA, Wang X, Manzanillo P, Li Y, Rutz S, Zheng Y, Diehl L, Kayagaki N, van Lookeren-Campagne M, Liesenfeld O, Heimesaat M, Ouyang W.

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Friday, October 9th, 2015 - Sandra (download presentation file)

Science. 2015 Oct 2;350(6256):aac5992. doi: 10.1126/science.aac5992.
Genetic determinants of in vivo fitness and diet responsiveness in multiple human gut Bacteroides.
Wu M, McNulty NP, Rodionov DA, Khoroshkin MS, Griffin NW, Cheng J, Latreille P, Kerstetter RA, Terrapon N, Henrissat B, Osterman AL, Gordon JI.

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Sci Transl Med. 2015 Sep 30;7(307):307ra152. doi: 10.1126/scitranslmed.aab2271.
Early infancy microbial and metabolic alterations affect risk of childhood asthma.
Arrieta MC, Stiemsma LT, Dimitriu PA, Thorson L, Russell S, Yurist-Doutsch S, Kuzeljevic B, Gold MJ, Britton HM, Lefebvre DL, Subbarao P, Mandhane P, Becker A, McNagny KM, Sears M, Kollmann T; CHILD Study Investigators, Mohn WW, Turvey SE, Brett Finlay B.

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Friday, September 25th, 2015 - Yasmin (download presentation file)

Immunity. 2015 Sep 15;43(3):541-53. doi: 10.1016/j.immuni.2015.08.007. Epub 2015 Aug 25.
Innate and Adaptive Humoral Responses Coat Distinct Commensal Bacteria with Immunoglobulin A.
Bunker JJ, Flynn TM, Koval JC, Shaw DG, Meisel M, McDonald BD, Ishizuka IE, Dent AL, Wilson PC, Jabri B, Antonopoulos DA, Bendelac A.

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Science. 2015 Sep 4;349(6252):1106-10. doi: 10.1126/science.aac6623.
Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells.
Schuijs MJ, Willart MA, Vergote K, Gras D, Deswarte K, Ege MJ, Madeira FB, Beyaert R, van Loo G, Bracher F, von Mutius E, Chanez P, Lambrecht BN, Hammad H.
Finlay BB.
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Friday, September 25th, 2015 - Yasmin (download presentation file)

Immunity. 2015 Sep 15;43(3):541-53. doi: 10.1016/j.immuni.2015.08.007. Epub 2015 Aug 25.
Innate and Adaptive Humoral Responses Coat Distinct Commensal Bacteria with Immunoglobulin A.
Bunker JJ, Flynn TM, Koval JC, Shaw DG, Meisel M, McDonald BD, Ishizuka IE, Dent AL, Wilson PC, Jabri B, Antonopoulos DA, Bendelac A.

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Science. 2015 Sep 4;349(6252):1106-10. doi: 10.1126/science.aac6623.
Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells.
Schuijs MJ, Willart MA, Vergote K, Gras D, Deswarte K, Ege MJ, Madeira FB, Beyaert R, van Loo G, Bracher F, von Mutius E, Chanez P, Lambrecht BN, Hammad H.
Finlay BB.
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Friday, September 11th, 2015 - Catherine (download presentation file)

Nat Med. 2015 Sep;21(9):1091-100. doi: 10.1038/nm.3929. Epub 2015 Aug 17.
In vivo imaging and tracking of host-microbiota interactions via metabolic labeling of gut anaerobic bacteria.
Geva-Zatorsky N, Alvarez D, Hudak JE, Reading NC, Erturk-Hasdemir D, Dasgupta S, von Andrian UH, Kasper DL.

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Nat Commun. 2015 Aug 4;6:7806. doi: 10.1038/ncomms8806.
Diet and specific microbial exposure trigger features of environmental enteropathy in a novel murine model.
Brown EM, Wlodarska M, Willing BP, Vonaesch P, Han J, Reynolds LA, Arrieta MC, Uhrig M, Scholz R, Partida O, Borchers CH, Sansonetti PJ, Finlay BB.

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Friday, August 28th, 2015 - Marcel (download presentation file)

Cell Host Microbe. 2015 Aug 12;18(2):198-209. doi: 10.1016/j.chom.2015.07.004.
Pathogenic NLRP3 Inflammasome Activity during Candida Infection Is Negatively Regulated by IL-22 via Activation of NLRC4 and IL-1Ra.
Borghi M, De Luca A, Puccetti M, Jaeger M, Mencacci A, Oikonomou V, Pariano M, Garlanda C, Moretti S, Bartoli A, Sobel J, van de Veerdonk FL, Dinarello CA, Netea MG, Romani L.

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Immunity. 2015 Aug 18;43(2):304-17. doi: 10.1016/j.immuni.2015.07.013. Epub 2015 Aug 4.
Pancreatic β-Cells Limit Autoimmune Diabetes via an Immunoregulatory Antimicrobial Peptide Expressed under the Influence of the Gut Microbiota.
Sun J, Furio L, Mecheri R, van der Does AM, Lundeberg E, Saveanu L, Chen Y, van Endert P, Agerberth B, Diana J.

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Friday, August 21st, 2015 - Stephanie (download presentation file)

Cell Rep. 2015 Aug 25;12(8):1314-24. doi: 10.1016/j.celrep.2015.07.040. Epub 2015 Aug 13.
Intestinal Monocyte-Derived Macrophages Control Commensal-Specific Th17 Responses.
Panea C, Farkas AM, Goto Y, Abdollahi-Roodsaz S, Lee C1, Koscsó B, Gowda K, Hohl TM, Bogunovic M, Ivanov II.

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Science. 2015 Aug 28;349(6251):993-7. doi: 10.1126/science.aaa9420. Epub 2015 Aug 13.
MUCOSAL IMMUNOLOGY. Individual intestinal symbionts induce a distinct population of RORγ⁺ regulatory T cells.
Sefik E, Geva-Zatorsky N, Oh S, Konnikova L, Zemmour D, McGuire AM, Burzyn D, Ortiz-Lopez A, Lobera M, Yang J, Ghosh S, Earl A, Snapper SB, Jupp R, Kasper D, Mathis D, Benoist C.

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Friday, August 14th, 2015 - Yasu (download presentation file)

Cell. 2015 Jul 2;162(1):170-83. doi: 10.1016/j.cell.2015.05.051. Epub 2015 Jun 18.
A Conserved Circular Network of Coregulated Lipids Modulates Innate Immune Responses.
Köberlin MS, Snijder B, Heinz LX, Baumann CL, Fauster A, Vladimer GI, Gavin AC, Superti-Furga G.

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Cell Metab. 2015 Jun 2;21(6):891-7. doi: 10.1016/j.cmet.2015.04.011. Epub 2015 May 7.
Metabolism links bacterial biofilms and colon carcinogenesis.
Johnson CH, Dejea CM, Edler D, Hoang LT, Santidrian AF, Felding BH, Ivanisevic J, Cho K, Wick EC, Hechenbleikner EM, Uritboonthai W, Goetz L, Casero RA Jr, Pardoll DM, White JR, Patti GJ, Sears CL, Siuzdak G.

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Friday, August 7th, 2015 - Medeleine (download presentation file)

Immunity. 2015 Jul 28. pii: S1074-7613(15)00258-7. doi: 10.1016/j.immuni.2015.06.014. [Epub ahead of print]
MyD88 Adaptor-Dependent Microbial Sensing by Regulatory T Cells Promotes Mucosal Tolerance and Enforces Commensalism.
Wang S, Charbonnier LM, Noval Rivas M, Georgiev P, Li N, Gerber G, Bry L, Chatila TA.

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Immunity. 2015 Jul 21;43(1):187-99. doi: 10.1016/j.immuni.2015.07.008.
Granulocyte Macrophage Colony-Stimulating Factor-Activated Eosinophils Promote Interleukin-23 Driven Chronic Colitis.
Griseri T, Arnold IC, Pearson C, Krausgruber T, Schiering C, Franchini F, Schulthess J, McKenzie BS, Crocker PR, Powrie F.

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Friday, July 24th, 2015 - Anna (download presentation file)

J Immunol. 2015 Jan 1;194(1):29-33. doi: 10.4049/jimmunol.1401704. Epub 2014 Nov 19.
Cutting edge: GPR35/CXCR8 is the receptor of the mucosal chemokine CXCL17.
Maravillas-Montero JL, Burkhardt AM, Hevezi PA, Carnevale CD, Smit MJ, Zlotnik A.

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Science. 2015 Jul 9. pii: aac4263. [Epub ahead of print]
The microbiota regulates type 2 immunity through RORγt+ T cells.
Ohnmacht C, Park JH, Cording S, Wing JB, Atarashi K, Obata Y, Gaboriau-Routhiau V, Marques R, Dulauroy S, Fedoseeva M, Busslinger M, Cerf-Bensussan N, Boneca IG, Voehringer D, Hase K, Honda K, Sakaguchi S, Eberl G.

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Friday, July 10th, 2015 - Mercedes (download presentation file)

Nat Immunol. 2015 Jun 29. doi: 10.1038/ni.3213. [Epub ahead of print]
Diversification of memory B cells drives the continuous adaptation of secretory antibodies to gut microbiota.
Lindner C, Thomsen I, Wahl B, Ugur M, Sethi MK, Friedrichsen M, Smoczek A, Ott S, Baumann U, Suerbaum S, Schreiber S, Bleich A, Gaboriau-Routhiau V, Cerf-Bensussan N, Hazanov H, Mehr R, Boysen P, Rosenstiel P, Pabst O1

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Immunity. 2015 Jun 26. pii: S1074-7613(15)00231-9. doi: 10.1016/j.immuni.2015.06.009. [Epub ahead of print]
Retinoic Acid Differentially Regulates the Migration of Innate Lymphoid Cell Subsets to the Gut.
Kim MH, Taparowsky EJ, Kim CH

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Friday, July 3rd, 2015 - Julien (download presentation file)

Cell. 2015 Feb 12;160(4):583-94. doi: 10.1016/j.cell.2014.12.038. Epub 2015 Jan 29.
Extensive strain-level copy-number variation across human gut microbiome species.
Greenblum S, Carr R, Borenstein E

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Nat Commun. 2015 Jun 30;6:7486. doi: 10.1038/ncomms8486.
Metabolic and metagenomic outcomes from early-life pulsed antibiotic treatment.
Nobel YR, Cox LM, Kirigin FF, Bokulich NA, Yamanishi S, Teitler I1, Chung J1, Sohn J1, Barber CM1, Goldfarb DS3, Raju K, Abubucker S, Zhou Y, Ruiz VE, Li H, Mitreva M, Alekseyenko AV, Weinstock GM, Sodergren E, Blaser MJ

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Friday, June 26th, 2015 - Li Hai (download presentation file)

Cell Host Microbe. 2015 Jun 10;17(6):763-74. doi: 10.1016/j.chom.2015.05.002. Epub 2015 May 28.
Salmonella Manipulation of Host Signaling Pathways Provokes Cellular Transformation Associated with Gallbladder Carcinoma.
Scanu T, Spaapen RM, Bakker JM, Pratap CB, Wu LE, Hofland I, Broeks A, Shukla VK, Kumar M, Janssen H, Song JY, Neefjes-Borst EA, Te Riele H, Holden DW, Nath G, Neefjes J

Guo X, Liang Y, Zhang Y, Lasorella A, Kee BL, Fu YX
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Nat Med. 2015 Jun 8. doi: 10.1038/nm.3871. [Epub ahead of print]
Activation of HIF-1α and LL-37 by commensal bacteria inhibits Candida albicans colonization.
Fan D, Coughlin LA, Neubauer MM, Kim J, Kim MS, Zhan X, Simms-Waldrip TR, Xie Y, Hooper LV, Koh AY

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Friday, June 19th, 2015 - Yasmin (download presentation file)

Immunity. 2015 Apr 21;42(4):731-43. doi: 10.1016/j.immuni.2015.03.012.
Innate Lymphoid Cells Control Early Colonization Resistance against Intestinal Pathogens through ID2-Dependent Regulation of the Microbiota.
Guo X, Liang Y, Zhang Y, Lasorella A, Kee BL, Fu YX

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Science. 2015 Jun 12;348(6240):1251-5. doi: 10.1126/science.aaa4921.
Innate immunity. Cytosolic detection of the bacterial metabolite HBP activates TIFA-dependent innate immunity.
Gaudet RG, Sintsova A, Buckwalter CM, Leung N, Cochrane A, Li J, Cox AD, Moffat J, Gray-Owen SD4

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Friday, June 12th, 2015 - Catherine and Sandra (download presentation file Sandra Catherine)

MBio. 2015 May 19;6(3). pii: e00022-15. doi: 10.1128/mBio.00022-15.
The bamboo-eating giant panda harbors a carnivore-like gut microbiota, with excessive seasonal variations.
Xue Z, Zhang W, Wang L, Hou R, Zhang M, Fei L, Zhang X, Huang H, Bridgewater LC, Jiang Y, Jiang C, Zhao L, Pang X, Zhang Z

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Nature. 2015 May 7;521(7550):90-3. doi: 10.1038/nature14139. Epub 2015 Feb 16.
Vertically transmitted faecal IgA levels determine extra-chromosomal phenotypic variation.
Moon C, Baldridge MT, Wallace MA, Burnham CA, Virgin HW, Stappenbeck TS

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Friday, June 5th, 2015 - Catherine (download presentation file)

Cell Host Microbe. 2015 May 13;17(5):617-27. doi: 10.1016/j.chom.2015.04.001. Epub 2015 Apr 30.
Humoral Immunity in the Gut Selectively Targets Phenotypically Virulent Attaching-and-Effacing Bacteria for Intraluminal Elimination.
Kamada N, Sakamoto K, Seo SU, Zeng MY, Kim YG, Cascalho M, Vallance BA, Puente JL, Núñez G

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Friday, May 29th, 2015 - Francesca (download presentation file)

Cell Host Microbe. 2015 May 13;17(5):681-9. doi: 10.1016/j.chom.2015.03.006. Epub 2015 Apr 16.
Effects of diurnal variation of gut microbes and high-fat feeding on host circadian clock function and metabolism.
Leone V, Gibbons SM, Martinez K, Hutchison AL, Huang EY, Cham CM, Pierre JF, Heneghan AF, Nadimpalli A, Hubert N, Zale E, Wang Y, Huang Y, Theriault B, Dinner AR, Musch MW, Kudsk KA, Prendergast BJ, Gilbert JA, Chang EB

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Nat Commun. 2015 Apr 1;6:6734. doi: 10.1038/ncomms7734.
Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome.
Macia L, Tan J, Vieira AT, Leach K, Stanley D, Luong S, Maruya M, Ian McKenzie C, Hijikata A, Wong C, Binge L, Thorburn AN, Chevalier N, Ang C, Marino E, Robert R, Offermanns S, Teixeira MM, Moore RJ, Flavell RA, Fagarasan S, Mackay CR

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Friday, May 22nd, 2015 - Stephi and Anna (download presentation file Stephi Anna)

Cell Host Microbe. 2015 May 13;17(5):690-703. doi: 10.1016/j.chom.2015.04.004.
Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life.
Bäckhed F, Roswall J, Peng Y, Feng Q, Jia H, Kovatcheva-Datchary P, Li Y, Xia Y, Xie H, Zhong H, Khan MT, Zhang J, Li J, Xiao L, Al-Aama J, Zhang D, Lee YS, Kotowska D, Colding C, Tremaroli V, Yin Y, Bergman S, Xu X, Madsen L, Kristiansen K, Dahlgren J, Jun W

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Immunity. 2015 Apr 21;42(4):744-55. doi: 10.1016/j.immuni.2015.03.004. Epub 2015 Apr 7.
Distinct Commensals Induce Interleukin-1β via NLRP3 Inflammasome in Inflammatory Monocytes to Promote Intestinal Inflammation in Response to Injury.
Seo SU, Kamada N, Muñoz-Planillo R, Kim YG, Kim D, Koizumi Y, Hasegawa M, Himpsl SD, Browne HP, Lawley TD, Mobley HL, Inohara N, Núñez G

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Friday, May 15th, 2015 - Marcel (download presentation file)

Nat Commun. 2014 Dec 5;5:5648. doi: 10.1038/ncomms6648.
Intestinal epithelial MyD88 is a sensor switching host metabolism towards obesity according to nutritional status.
Everard A, Geurts L, Caesar R, Van Hul M, Matamoros S, Duparc T, Denis RG, Cochez P, Pierard F, Castel J, Bindels LB, Plovier H, Robine S, Muccioli GG, Renauld JC, Dumoutier L, Delzenne NM, Luquet S, Bäckhed F, Cani PD

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Mucosal Immunol. 2015 Apr 29. doi: 10.1038/mi.2015.27. [Epub ahead of print]
Colonic MUC2 mucin regulates the expression and antimicrobial activity of β-defensin 2.
Cobo ER, Kissoon-Singh V, Moreau F, Chadee K

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Friday, May 8th, 2015 - Madeleine (download presentation file)

Nature. 2015 Apr 29. doi: 10.1038/nature14452. [Epub ahead of print]
Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation.
Gagliani N, Vesely MC, Iseppon A, Brockmann L, Xu H, Palm NW, de Zoete MR, Licona-Limón P, Paiva RS, Ching T, Weaver C, Zi X, Pan X, Fan R, Garmire LX, Cotton MJ, Drier Y, Bernstein B, Geginat J, Stockinger B, Esplugues E, Huber S, Flavell RA

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Friday, May 1st, 2015 - Anna (download presentation file)

Immunity. 2015 Apr 21;42(4):744-55. doi: 10.1016/j.immuni.2015.03.004. Epub 2015 Apr 7.
Distinct Commensals Induce Interleukin-1β via NLRP3 Inflammasome in Inflammatory Monocytes to Promote Intestinal Inflammation in Response to Injury.
Seo SU, Kamada N, Muñoz-Planillo R, Kim YG, Kim D, Koizumi Y, Hasegawa M, Himpsl SD, Browne HP, Lawley TD, Mobley HL, Inohara N, Núñez G

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Friday, April 17th, 2015 - Yasu (download presentation file)

Immunity. 2015 Mar 17;42(3):419-30. doi: 10.1016/j.immuni.2015.02.005.
Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization.
Jha AK, Huang SC, Sergushichev A, Lampropoulou V, Ivanova Y, Loginicheva E, Chmielewski K, Stewart KM, Ashall J, Everts B, Pearce EJ, Driggers EM, Artyomov MN.

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Cell Host Microbe. 2014 Dec 10;16(6):759-69. doi: 10.1016/j.chom.2014.11.005.
The gut commensal bacteroides thetaiotaomicron exacerbates enteric infection through modification of the metabolic landscape.
Curtis MM, Hu Z, Klimko C, Narayanan S, Deberardinis R, Sperandio V.

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Friday, April 10th, 2015 - Julien (download presentation file)

Cell Rep. 2015 Mar 18. pii: S2211-1247(15)00207-7. doi: 10.1016/j.celrep.2015.02.049. [Epub ahead of print]
Manipulation of the Quorum Sensing Signal AI-2 Affects the Antibiotic-Treated Gut Microbiota.
Thompson JA, Oliveira RA, Djukovic A, Ubeda C, Xavier KB.

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Mol Syst Biol. 2015 Mar 11;11:788. doi: 10.15252/msb.20145866.
Improving microbial fitness in the mammalian gut by in vivo temporal functional metagenomics.
Yaung SJ, Deng L, Li N, Braff JL, Church GM, Bry L, Wang HH, Gerber GK.

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Friday, April 10th, 2015 - Julien (download presentation file)


Friday, March 27th, 2015 - Li Hai (download presentation file)

Science. 2015 Mar 19. pii: aaa7017. [Epub ahead of print]RegulatoryT cells generated early in life play a distinct role in maintaining self-tolerance.Yang S, Fujikado N, Kolodin D, Benoist C, Mathis D
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Cell Host Microbe. 2015 Mar 11;17(3):385-91. doi: 10.1016/j.chom.2015.01.015. Epub 2015 Feb 26.
Biogeography of the intestinal mucosal and lumenal microbiome in the rhesus macaque.
Yasuda K, Oh K, Ren B, Tickle TL, Franzosa EA, Wachtman LM, Miller AD, Westmoreland SV, Mansfield KG, Vallender EJ, Miller GM, Rowlett JK, Gevers D, Huttenhower C, Morgan XC.

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Friday, March 13th, 2015 - Mercedes (download presentation file)

Cell Metab. 2015 Feb 3;21(2):286-97. doi: 10.1016/j.cmet.2015.01.004.
Identification of natural RORγ ligands that regulate the development of lymphoid cells.
Santori FR, Huang 2, van de Pavert SA, Douglass EF Jr, Leaver DJ, Haubrich BA, Keber R, Lorbek G, Konijn T, Rosales BN, Rozman D, Horvat S, Rahier A, Mebius RE, Rastinejad F, Nes WD, Littman DR

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Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):1929-36. doi: 10.1073/pnas.1424886112.
Analysis of gene-environment interactions in postnatal development of the mammalian intestine.
Rakoff-Nahoum S, Kong Y, Kleinstein SH, Subramanian S, Ahern PP, Gordon JI, Medzhitov R

Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):1929-36. doi: 10.1073/pnas.1424886112. Analysis of gene-environment interactions in postnatal development of the mammalian intestine. Rakoff-Nahoum S, Kong Y, Kleinstein SH, Subramanian S, Ahern PP, Gordon JI, Medzhitov R
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Friday, March 6th, 2015 - Francesca (download presentation file)

Cell Host Microbe. 2015 Feb 11;17(2):260-73. doi: 10.1016/j.chom.2015.01.001. Epub 2015 Feb 5.
The Dynamics of the Human Infant Gut Microbiome in Development and in Progression toward Type 1 Diabetes.
Kostic AD, Gevers D, Siljander H, Vatanen T, Hyötyläinen T, Hämäläinen AM, Peet A, Tillmann V, Pöhö P, Mattila I, Lähdesmäki H, Franzosa EA, Vaarala O, de Goffau M, Harmsen H, Ilonen J, Virtanen SM, Clish CB, Orešič M, Huttenhower C, Knip M; DIABIMMUNE Study Group, Xavier RJ

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Nature. 2015 Feb 25. doi: 10.1038/nature14232. [Epub ahead of print]
Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome.
Chassaing B, Koren O, Goodrich JK, Poole AC, Srinivasan S, Ley RE, Gewirtz AT

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Friday, Feb. 6th, 2015 - Stephanie (download presentation file)

Science. 2015 Jan 9;347(6218):170-5. doi: 10.1126/science.1260580.
Gut microbiota. Antimicrobial peptide resistance mediates resilience of prominent gut commensals during inflammation.
Cullen TW, Schofield WB, Barry NA, Putnam EE, Rundell EA, Trent MS, Degnan PH, Booth CJ, Yu H, Goodman AL.

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Cell Host Microbe. 2015 Jan 22. pii: S1931-3128(14)00463-6. doi: 10.1016/j.chom.2014.12.009. [Epub ahead of print]
MyD88 Signaling in T Cells Directs IgA-Mediated Control of the Microbiota to Promote Health.
Kubinak JL, Petersen C, Stephens WZ, Soto R, Bake E, O'Connell RM, Round JL.

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Friday, Jan. 30th, 2015 - Yasmin (download presentation file)

Nature. 2015 Jan 19. doi: 10.1038/nature14027. [Epub ahead of print]
Growth and host interaction of mouse segmented filamentous bacteria in vitro.
Schnupf P, Gaboriau-Routhiau V, Gros M, Friedman R, Moya-Nilges M, Nigro G, Cerf-Bensussan N, Sansonetti PJ

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Mucosal Immunol. 2015 Jan 7. doi: 10.1038/mi.2014.123. [Epub ahead of print]
IL-1β in eosinophil-mediated small intestinal homeostasis and IgA production.
Jung Y, Wen T, Mingler MK, Caldwell JM, Wang YH, Chaplin DD, Lee EH, Jang MH, Woo SY, Seoh JY, Miyasaka M, Rothenberg ME.

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Friday, Jan. 23rd, 2015 - Catherine (download presentation file)

Cell Host Microbe. 2015 Jan 14;17(1):72-84. doi: 10.1016/j.chom.2014.11.010. Epub 2014 Dec 18.
Diet dominates host genotype in shaping the murine gut microbiota.
Carmody RN, Gerber GK, Luevano JM Jr, Gatti DM, Somes L, Svenson KL, Turnbaugh PJ.

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Nature. 2015 Jan 8;517(7533):165-9. doi: 10.1038/nature13995.
Human gut Bacteroidetes can utilize yeast mannan through a selfish mechanism.
Cuskin F, Lowe EC, Temple MJ, Zhu Y, Cameron EA, Pudlo NA, Porter NT, Urs K, Thompson AJ, Cartmell A, Rogowski A, Hamilton BS, Chen R, Tolbert TJ, Piens K, Bracke D, Vervecken W, Hakki Z, Speciale G, Munōz-Munōz JL, Day A, Peña MJ, McLean R, Suits MD, Boraston AB, Atherly T, Ziemer CJ, Williams SJ, Davies GJ, Abbott DW1, Martens EC, Gilbert HJ.

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Friday, Jan. 9th, 2015 - Yasu (download presentation file)

Cell. 2014 Oct 9;159(2):318-32. doi: 10.1016/j.cell.2014.09.035.
Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects.
Yore MM, Syed I, Moraes-Vieira PM, Zhang T, Herman MA, Homan EA, Patel RT, Lee J, Chen S, Peroni OD, Dhaneshwar AS, Hammarstedt A, Smith U, McGraw TE, Saghatelian A, Kahn BB.

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Cell Host Microbe. 2014 Oct 8;16(4):495-503. doi: 10.1016/j.chom.2014.09.001. Epub 2014 Sep 25.
Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine.
Williams BB, Van Benschoten AH, Cimermancic P, Donia MS, Zimmermann M, Taketani M, Ishihara A, Kashyap PC, Fraser JS, Fischbach MA.

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