Journal Club 2014



Friday, Dec. 19th, 2014 - Sandra (download presentation file)

Cell. 2014 Dec 4;159(6):1277-89. doi: 10.1016/j.cell.2014.10.053.
Gut Microbiota Elicits a Protective Immune Response against Malaria Transmission.
Yilmaz B, Portugal S, Tran TM, Gozzelino R, Ramos S, Gomes J, Regalado A, Cowan PJ, d'Apice AJ, Chong AS, Doumbo OK, Traore B, Crompton PD, Silveira H, Soares MP.

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J Exp Med. 2014 Nov 17;211(12):2331-9. doi: 10.1084/jem.20141404. Epub 2014 Oct 27.
Staphylococcus aureus infection induces protein A-mediated immune evasion in humans.
Pauli NT, Kim HK, Falugi F, Huang M, Dulac J, Henry Dunand C, Zheng NY, Kaur K, Andrews SF, Huang Y, DeDent A, Frank KM, Charnot-Katsikas A, Schneewind O, Wilson PC.

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Friday, Dec. 12th, 2014 - Anna (download presentation file)

J Exp Med. 2014 Dec 15;211(13):2683. doi: 10.1084/jem.2014062511242014c. Epub 2014 Dec 8.
Respiratory influenza virus infection induces intestinal immune injury via microbiota-mediated Th17 cell-dependent inflammation.
Wang J, Li F, Wei H, Lian ZX, Sun R, Tian Z.

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Immunity. 2014 Nov 20;41(5):776-88. doi: 10.1016/j.immuni.2014.10.007. Epub 2014 Nov 6.
The Chemokine Receptor CXCR6 Controls the Functional Topography of Interleukin-22 Producing Intestinal Innate Lymphoid Cells.
Satoh-Takayama N, Serafini N, Verrier T, Rekiki A, Renauld JC, Frankel G, Di Santo JP.

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Friday, Nov. 28th, 2014 - William (download presentation file)

Nature. 2014 Nov 19. doi: 10.1038/nature13960. [Epub ahead of print]
An enteric virus can replace the beneficial function of commensal bacteria.
Kernbauer E, Ding Y, Cadwell K.

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Immunity. 2014 Oct 16;41(4):620-32. doi: 10.1016/j.immuni.2014.09.010.
Interleukin-22 Regulates the Complement System to Promote Resistance against Pathobionts after Pathogen-Induced Intestinal Damage.
Hasegawa M, Yada S, Liu MZ, Kamada N, Muñoz-Planillo R, Do N, Núñez G, Inohara N.

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Friday, Nov. 21st, 2014 - Mercedes (download presentation file)

Nat Med. 2014 Nov;20(11):1327-33. doi: 10.1038/nm.3704. Epub 2014 Oct 5.
De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells.
Berod L, Friedrich C, Nandan A, Freitag J, Hagemann S, Harmrolfs K, Sandouk A, Hesse C, Castro CN, Bähre H, Tschirner SK, Gorinski N, Gohmert M, Mayer CT, Huehn J, Ponimaskin E, Abraham WR, Müller R, Lochner M, Sparwasser T.

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Nat Med. 2014 Nov;20(11):1334-9. doi: 10.1038/nm.3680. Epub 2014 Oct 19.
Regulatory B cells are induced by gut microbiota-driven interleukin-1β and interleukin-6 production.
Rosser EC, Oleinika K, Tonon S, Doyle R, Bosma A, Carter NA, Harris KA, Jones SA, Klein N, Mauri C.

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Friday, Nov. 10th, 2014 - Julien (download presentation file)

Cell. 2014 Nov 6;159(4):789-99. doi: 10.1016/j.cell.2014.09.053.
Human genetics shape the gut microbiome.
Goodrich JK, Waters JL, Poole AC, Sutter JL, Koren O, Blekhman R, Beaumont M, Van Treuren W, Knight R, Bell JT, Spector TD, Clark AG, Ley RE.

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Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16431-5. doi: 10.1073/pnas.1419136111. Epub 2014 Nov 3.
Rapid changes in the gut microbiome during human evolution.
Moeller AH, Li Y, Mpoudi Ngole E, Ahuka-Mundeke S, Lonsdorf EV, Pusey AE, Peeters M, Hahn BH, Ochman H.

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Friday, Nov. 6th, 2014 - Li Hai (download presentation file)

Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):13942-7. doi: 10.1073/pnas.1323852111. Epub 2014 Sep 8.
Homeostatic IL-23 receptor signaling limits Th17 response through IL-22-mediated containment of commensal microbiota.
Shih VF, Cox J, Kljavin NM, Dengler HS, Reichelt M, Kumar P, Rangell L, Kolls JK, Diehl L, Ouyang W, Ghilardi N.

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Nature. 2014 Sep 28. doi: 10.1038/nature13788. [Epub ahead of print]
Dietary modulation of the microbiome affects autoinflammatory disease.
Lukens JR, Gurung P, Vogel P, Johnson GR, Carter RA, McGoldrick DJ, Bandi SR, Calabrese CR, Walle LV, Lamkanfi M, Kanneganti TD.

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Friday, October 31st, 2014 - Stephanie (download presentation file)

Immunity. 2014 Aug 21;41(2):283-95. doi: 10.1016/j.immuni.2014.06.016. Epub 2014 Jul 31.
MHCII-mediated dialog between group 2 innate lymphoid cells and CD4(+) T cells potentiates type 2 immunity and promotes parasitic helminth expulsion.
Oliphant CJ, Hwang YY, Walker JA, Salimi M, Wong SH, Brewer JM, Englezakis A, Barlow JL, Hams E, Scanlon ST, Ogg GS, Fallon PG, McKenzie AN.

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Cell. 2014 Oct 23;159(3):514-29. doi: 10.1016/j.cell.2014.09.048. Epub 2014 Oct 16.
Transkingdom control of microbiota diurnal oscillations promotes metabolic homeostasis.
Thaiss CA, Zeevi D, Levy M, Zilberman-Schapira G, Suez J, Tengeler AC, Abramson L, Katz MN, Korem T, Zmora N, Kuperman Y, Biton I5, Gilad S6, Harmelin A5, Shapiro H, Halpern Z, Segal E, Elinav E.

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Friday, October 24th, 2014 - Anna (download presentation file)

Cell. 2014 Oct 9;159(2):253-66. doi: 10.1016/j.cell.2014.09.008. Epub 2014 Oct 2.
Bacteria from diverse habitats colonize and compete in the mouse gut.
Seedorf H, Griffin NW, Ridaura VK, Reyes A, Cheng J, Rey FE, Smith MI, Simon GM, Scheffrahn RH, Woebken D, Spormann AM, Van Treuren W, Ursell LK, Pirrung M, Robbins-Pianka A, Cantarel BL, Lombard V, Henrissat B, Knight R, Gordon JI.

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Mucosal Immunol. 2014 Nov;7(6):1290-301. doi: 10.1038/mi.2014.17. Epub 2014 Mar 19.
Regulatory T cells promote a protective Th17-associated immune response to intestinal bacterial infection with C. rodentium.
Wang Z, Friedrich C, Hagemann SC, Korte WH, Goharani N, Cording S, Eberl G, Sparwasser T, Lochner M.

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Friday, October 17th, 2014 - Yasmin (download presentation file)

Nature. 2014 Oct 30;514(7524):638-41. doi: 10.1038/nature13823. Epub 2014 Oct 1.
Rapid fucosylation of intestinal epithelium sustains host-commensal symbiosis in sickness.
Pickard JM, Maurice CF, Kinnebrew MA, Abt MC, Schenten D, Golovkina TV, Bogatyrev SR, Ismagilov RF, Pamer EG, Turnbaugh PJ, Chervonsky AV.

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Cell Host Microbe. 2014 Oct 8;16(4):504-16. doi: 10.1016/j.chom.2014.08.017. Epub 2014 Sep 25.
Epithelial IL-22RA1-Mediated Fucosylation Promotes Intestinal Colonization Resistance to an Opportunistic Pathogen.
Pham TA, Clare S, Goulding D, Arasteh JM, Stares MD, Browne HP, Keane JA, Page AJ, Kumasaka N, Kane L, Mottram L, Harcourt K, Hale C, Arends MJ, Gaffney DJ; Sanger Mouse Genetics Project, Dougan G, Lawley TD.

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Friday, October 10th, 2014 - Yasu (download presentation file)

Nature. 2014 Sep 17. doi: 10.1038/nature13738. [Epub ahead of print]
Members of the human gut microbiota involved in recovery from Vibrio cholerae infection.
Hsiao A, Ahmed AM, Subramanian S, Griffin NW, Drewry LL, Petri WA, Haque R, Ahmed T, Gordon JI.

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Science. 2014 Sep 26;345(6204):1251086. doi: 10.1126/science.1251086.
Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity.
Saeed S, Quintin J, Kerstens HH, Rao NA, Aghajanirefah A, Matarese F, Cheng SC, Ratter J, Berentsen K, van der Ent MA, Sharifi N, Janssen-Megens EM, Ter Huurne M, Mandoli A, van Schaik T, Ng A, Burden F, Downes K, Frontini M, Kumar V, Giamarellos-Bourboulis EJ, Ouwehand WH, van der Meer JW, Joosten LA, Wijmenga C, Martens JH, Xavier RJ, Logie C, Netea MG, Stunnenberg HG.

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Friday, October 3rd, 2014 - Francesca (download presentation file)

Nature. 2014 Sep 17. doi: 10.1038/nature13793. [Epub ahead of print]
Artificial sweeteners induce glucose intolerance by altering the gut microbiota.
Suez J, Korem T, Zeevi D, Zilberman-Schapira G, Thaiss CA, Maza O, Israeli D, Zmora N, Gilad S, Weinberger A, Kuperman Y, Harmelin A, Kolodkin-Gal I, Shapiro H, Halpern Z, Segal E, Elinav E.

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Science. 2014 Aug 28. pii: 1257530. [Epub ahead of print]
A local macrophage chemokine network sustains protective tissue-resident memory CD4 T cells.
Iijima N, Iwasaki A.

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Friday, September 26th, 2014 - Catherine (download presentation file)

Immunity. 2014 Sep 18;41(3):478-92. doi: 10.1016/j.immuni.2014.08.009. Epub 2014 Sep 11.
TLR5-Mediated Sensing of Gut Microbiota Is Necessary for Antibody Responses to Seasonal Influenza Vaccination.
Oh JZ, Ravindran R, Chassaing B, Carvalho FA, Maddur MS, Bower M, Hakimpour P, Gill KP, Nakaya HI, Yarovinsky F, Sartor RB, Gewirtz AT, Pulendran B.

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Cell. 2014 Aug 28;158(5):1000-10. doi: 10.1016/j.cell.2014.08.006.
Immunoglobulin a coating identifies colitogenic bacteria in inflammatory bowel disease.
Palm NW, de Zoete MR, Cullen TW, Barry NA, Stefanowski J, Hao L, Degnan PH, Hu J, Peter I, Zhang W, Ruggiero E, Cho JH, Goodman AL, Flavell RA.

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​​Friday, September 12th, 2014 - Sandra (download presentation file)


Nat Immunol. 2014 Oct;15(10):973-81. doi: 10.1038/ni.2965. Epub 2014 Aug 24.
B cell homeostasis and follicle confines are governed by fibroblastic reticular cells.
Cremasco V, Woodruff MC, Onder L, Cupovic J, Nieves-Bonilla JM, Schildberg FA, Chang J, Cremasco F, Harvey CJ, Wucherpfennig K, Ludewig B, Carroll MC, Turley SJ.

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J Immunol. 2014 Oct 1;193(7):3492-502. doi: 10.4049/jimmunol.1400798. Epub 2014 Aug 29.
CD4+ T Cells and CD40 Participate in Selection and Homeostasis of Peripheral B Cells.
Schwartz MA, Kolhatkar NS, Thouvenel C, Khim S, Rawlings DJ.

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Friday, September 5th, 2014 - William (download presentation file)

Nature. 2014 Aug 31. doi: 10.1038/nature13398. [Epub ahead of print]
High-fat-diet-mediated dysbiosis promotes intestinal carcinogenesis independently of obesity.
Schulz MD, Atay C, Heringer J, Romrig FK, Schwitalla S, Aydin B, Ziegler PK, Varga J, Reindl W, Pommerenke C, Salinas-Riester G, Böck A, Alpert C, Blaut M, Polson SC, Brandl L, Kirchner T, Greten FR, Polson SW, Arkan MC.

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Immunity. 2014 Aug 21;41(2):296-310. doi: 10.1016/j.immuni.2014.06.014. Epub 2014 Jul 24.
Symbiotic Bacterial Metabolites Regulate Gastrointestinal Barrier Function via the Xenobiotic Sensor PXR and Toll-like Receptor 4.
Venkatesh M, Mukherjee S, Wang H, Li H, Sun K, Benechet AP, Qiu Z, Maher L, Redinbo MR, Phillips RS, Fleet JC, Kortagere S, Mukherjee P, Fasano A, Le Ven J, Nicholson JK, Dumas ME, Khanna KM, Mani S.

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​Friday, August 29th, 2014 - Mercedes Gomez (download presentation file)

J Exp Med. 2014 Jul 28;211(8):1571-83. doi: 10.1084/jem.20140678. Epub 2014 Jul 14.
CX3CR1+ mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22.
Longman RS, Diehl GE, Victorio DA, Huh JR, Galan C, Miraldi ER, Swaminath A, Bonneau R, Scherl EJ, Littman DR.

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Science. 2014 Aug, AOP DOI: 10.1126/science.1254009
Innate lymphoid cells regulate intestinal epithelial cell glycosylation
Yoshiyuki Goto, Takashi Obata, Jun Kunisawa, Shintaro Sato, Ivaylo I. Ivanov, Aayam Lamichhane, Natsumi Takeyama, Mariko Kamioka, Mitsuo Sakamoto, Takahiro Matsuki, Hiromi Setoyama, Akemi Imaoka, Satoshi Uematsu, Shizuo Akira, Steven E. Domino, Paulina Kulig, Burkhard Becher, Jean-Christophe Renauld, Chihiro Sasakawa, Yoshinori Umesaki, Yoshimi Benno, Hiroshi Kiyono

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Friday, August 22nd, 2014 - Julien (download presentation file)

Cell. 2014 Aug 14;158(4):722-33.
Phenotypic variation of salmonella in host tissues delays eradication by antimicrobial chemotherapy.
Claudi B, Spröte P, Chirkova A, Personnic N, Zankl J, Schürmann N, Schmidt A, Bumann D.

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Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):12153-8.
Inactivation of a single gene enables microaerobic growth of the obligate anaerobe Bacteroides fragilis.
Meehan BM1, Baughn AD, Gallegos R, Malamy MH.

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Friday, August 15th, 2014 - Li Hai (download presentation file)

Nature. 2014 Oct 9;514(7521):237-41. doi: 10.1038/nature13564. Epub 2014 Aug 6.
Interleukin-22 alleviates metabolic disorders and restores mucosal immunity in diabetes.
Wang X, Ota N, Manzanillo P, Kates L, Zavala-Solorio J, Eidenschenk C, Zhang J, Lesch J, Lee WP, Ross J, Diehl L, van Bruggen N, Kolumam G, Ouyang W.

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Cell Host Microbe. 2014 Aug 13;16(2):227-36. doi: 10.1016/j.chom.2014.07.007. Epub 2014 Jul 25.
A type VI secretion-related pathway in Bacteroidetes mediates interbacterial antagonism.
Russell AB, Wexler AG, Harding BN, Whitney JC, Bohn AJ, Goo YA, Tran BQ, Barry NA, Zheng H, Peterson SB, Chou S, Gonen T, Goodlett DR, Goodman AL, Mougous JD.

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Friday, August 8th, 2014 - Stephanie (download presentation file)

Nature. 2014 Jul 16. doi: 10.1038/nature13577. [Epub ahead of print]
The alarmin IL-33 promotes regulatory T-cell function in the intestine.
Schiering C, Krausgruber T, Chomka A, Fröhlich A, Adelmann K, Wohlfert EA, Pott J, Griseri T, Bollrath J, Hegazy AN, Harrison OJ, Owens BM, Löhning M, Belkaid Y, Fallon PG, Powrie F.

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Immunity. 2014 Jul 30. pii: S1074-7613(14)00241-6. doi: 10.1016/j.immuni.2014.06.015. [Epub ahead of print]
Bacterial Sensor Nod2 Prevents Inflammation of the Small Intestine by Restricting the Expansion of the Commensal Bacteroides vulgatus.
Ramanan D, Tang MS, Bowcutt R, Loke P, Cadwell K.

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Friday, July 25th, 2014 - Yasmin (download presentation file)

Immunity. 2014 Jul 17;41(1):141-51. doi: 10.1016/j.immuni.2014.05.017. Epub 2014 Jul 10.
Immunoglobulin E Signal Inhibition during Allergen Ingestion Leads to Reversal of Established Food Allergy and Induction of Regulatory T Cells.
Burton OT, Noval Rivas M, Zhou JS, Logsdon SL, Darling AR, Koleoglou KJ, Roers A, Houshyar H, Crackower MA, Chatila TA, Oettgen HC.

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Cell. 2014 Jul 17;158(2):300-13. doi: 10.1016/j.cell.2014.04.050.
Crosstalk between Muscularis Macrophages and Enteric Neurons Regulates Gastrointestinal Motility.
Muller PA, Koscsó B, Rajani GM, Stevanovic K, Berres ML, Hashimoto D, Mortha A, Leboeuf M, Li XM, Mucida D, Stanley ER, Dahan S, Margolis KG, Gershon MD, Merad M, Bogunovic M.

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Friday, July 18th, 2014 - Yasu (presentation file) and Sandra(download presentation file)

Nat Immunol. 2014 Jul;15(7):676-86. doi: 10.1038/ni.2920. Epub 2014 Jun 8.
TH9 cells that express the transcription factor PU.1 drive T cell-mediated colitis via IL-9 receptor signaling in intestinal epithelial cells.
Gerlach K, Hwang Y, Nikolaev A, Atreya R, Dornhoff H, Steiner S, Lehr HA, Wirtz S, Vieth M, Waisman A, Rosenbauer F, McKenzie AN, Weigmann B, Neurath MF.

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Nature. 2014 Jul 10;511(7508):184-90. doi: 10.1038/nature13323.
Aryl hydrocarbon receptor control of a disease tolerance defence pathway.
Bessede A, Gargaro M, Pallotta MT, Matino D, Servillo G, Brunacci C, Bicciato S, Mazza EM, Macchiarulo A, Vacca C, Iannitti R, Tissi L, Volpi C, Belladonna ML, Orabona C, Bianchi R, Lanz TV, Platten M, Della Fazia MA, Piobbico D, Zelante T, Funakoshi H, Nakamura T, Gilot D, Denison MS, Guillemin GJ, DuHadaway JB, Prendergast GC, Metz R, Geffard M, Boon L, Pirro M, Iorio A, Veyret B, Romani L, Grohmann U, Fallarino F, Puccetti P.

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Friday, July 11th, 2014 - Francesca Ronchi (download presentation file)

Immunity. 2014 Jan 16;40(1):128-39. doi: 10.1016/j.immuni.2013.12.007. Epub 2014 Jan 9.
Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis.
Singh N1, Gurav A, Sivaprakasam S, Brady E, Padia R, Shi H, Thangaraju M, Prasad PD, Manicassamy S, Munn DH5, Lee JR, Offermanns S, Ganapathy V.

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Mucosal Immunol. 2014 Jun 18. doi: 10.1038/mi.2014.51. [Epub ahead of print]
Unique lamina propria stromal cells imprint the functional phenotype of mucosal dendritic cells.
Vicente-Suarez I, Larange A, Reardon C, Matho M, Feau S, Chodaczek G, Park Y, Obata Y, Gold R, Wang-Zhu Y, Lena C, Zajonc DM, Schoenberger SP, Kronenberg M, Cheroutre H.

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Friday, July 4th, 2014 - Anna Steinert (download presentation file)

Immunity. 2014 Feb 20;40(2):248-61.
Oral tolerance can be established via gap junction transfer of fed antigens from CX3CR1+ macrophages to CD103+ dendritic cells.

Mazzini E, Massimiliano L, Penna G, Rescigno M.
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Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):5986-91.
Differentiation of CD11c+ CX3CR1+ cells in the small intestine requires Notch signaling.

Ishifune C, Maruyama S, Sasaki Y, Yagita H, Hozumi K, Tomita T, Kishihara K, Yasutomo K.
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​​Friday, June 20th, 2014 - Sandra Rupp (download presentation file)

Nature. 2014 May 29;509(7502):637-40.
Clonal selection in the germinal centre by regulated proliferation and hypermutation.
Gitlin AD, Shulman Z, Nussenzweig MC.

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Sci Transl Med. 2014 May 28;6(238):238ra72.
CD4 T cells with effector memory phenotype and function develop in the sterile environment of the fetus.
Zhang X, Mozeleski B, Lemoine S, Dériaud E, Lim A, Zhivaki D, Azria E, Le Ray C, Roguet G, Launay O, Vanet A, Leclerc C, Lo-Man R.

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​Friday, June 13th, 2014 - William Kwong Chung (download presentation file)

Immunity. 2014 May 15;40(5):720-33. doi: 10.1016/j.immuni.2014.03.012.
Macrophage-Restricted Interleukin-10 Receptor Deficiency, but Not IL-10 Deficiency, Causes Severe Spontaneous Colitis
Ehud Zigmond, Biana Bernshtein, Gilgi Friedlander, Catherine R. Walker, Simon Yona, Ki-Wook Kim, Ori Brenner, Rita Krauthgamer, Chen Varol, Werner Müller, and Steffen Jung
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Immunity. 2014 May 15;40(5):706-19. doi: 10.1016/j.immuni.2014.03.011.
Interleukin-10 Receptor Signaling in Innate Immune Cells Regulates Mucosal Immune Tolerance and Anti-Inflammatory Macrophage Function

Dror S. Shouval, Amlan Biswas, Jeremy A. Goettel, Katelyn McCann, Evan Conaway, Naresh S. Redhu, Ivan D. Mascanfroni, Ziad Al Adham, Sydney Lavoie, Mouna Ibourk, Deanna D. Nguyen, Janneke N. Samsom, Johanna C. Escher, Raz Somech, Batia Weiss, Rita Beier, Laurie S. Conklin, Christen L. Ebens, Fernanda G.M.S. Santos, Alexandre R. Ferreira, Mary Sherlock, Atul K. Bhan, Werner Muüller, J. Rodrigo Mora, Francisco J. Quintana, Christoph Klein, Aleixo M. Muise, Bruce H. Horwitz, and Scott B. Snapper
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Friday, June 6th, 2014 - Julien Limenitakis (download presentation file)

Proc Natl Acad Sci U S A. 2014 May 19. pii: 201319284. [Epub ahead of print]
Relating the metatranscriptome and metagenome of the human gut.
Franzosa EA, Morgan XC, Segata N, Waldron L, Reyes J, Earl AM, Giannoukos G, Boylan MR, Ciulla D, Gevers D, Izard J, Garrett WS, Chan AT, Huttenhower C.
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Cell Host Microbe. 2014 Jan 15;15(1):47-57. doi: 10.1016/j.chom.2013.12.007.
Human gut microbes use multiple transporters to distinguish vitamin B₁₂ analogs and compete in the gut.
Degnan PH, Barry NA, Mok KC, Taga ME, Goodman AL.

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Friday, May 30th, 2014 - Li Hai (download presentation file)

Nature. 2014 May 15;509(7500):357-60. doi: 10.1038/nature13178. Epub 2014 Apr 16.
Dynamics and associations of microbial community types across the human body.
Ding T, Schloss PD.

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Immunity. 2014 Apr 17;40(4):608-20. doi: 10.1016/j.immuni.2014.03.009.
Segmented filamentous bacterium uses secondary and tertiary lymphoid tissues to induce gut IgA and specific T helper 17 cell responses.
Lécuyer E, Rakotobe S, Lengliné-Garnier H, Lebreton C, Picard M, Juste C, Fritzen R, Eberl G, McCoy KD, Macpherson AJ, Reynaud CA, Cerf-Bensussan N, Gaboriau-Routhiau V.

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Friday, May 9th, 2014 - Mercedes (download presentation file)

Nature. 2014 Apr 3;508(7494):123-7. doi: 10.1038/nature13158. Epub 2014 Mar 19.
Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity.
van de Pavert SA, Ferreira M, Domingues RG, Ribeiro H, Molenaar R, Moreira-Santos L, Almeida FF, Ibiza S, Barbosa I, Goverse G, Labão-Almeida C, Godinho-Silva C, Konijn T, Schooneman D, O'Toole T, Mizee MR, Habani Y, Haak E, Santori FR, Littman DR, Schulte-Merker S, Dzierzak E, Simas JP, Mebius RE, Veiga-Fernandes H.

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Nat Med. 2014 Apr 20. doi: 10.1038/nm.3542. [Epub ahead of print]
The microbiota regulates neutrophil homeostasis and host resistance to Escherichia coli K1 sepsis in neonatal mice.
Deshmukh HS, Liu Y, Menkiti OR, Mei J, Dai N, O'Leary CE, Oliver PM, Kolls JK, Weiser JN, Worthen GS.

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Friday, May 2nd, 2014 - Yasmin (download presentation file)

Nat Immunol. 2011 Feb;12(2):151-9. doi: 10.1038/ni.1981. Epub 2011 Jan 9.
Eosinophils are required for the maintenance of plasma cells in the bone marrow.
Chu VT, Fröhlich A, Steinhauser G, Scheel T, Roch T, Fillatreau S, Lee JJ, Löhning M, Berek C.

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Immunity. 2014 Apr 17;40(4):582-93. doi: 10.1016/j.immuni.2014.02.014.
Eosinophils promote generation and maintenance of immunoglobulin-a-expressing plasma cells and contribute to gut immune homeostasis.
Chu VT, Beller A, Rausch S, Strandmark J, Zänker M, Arbach O, Kruglov A, Berek C.

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Friday, April 25th, 2014 - Stephanie (download presentation file)

Nature. 2014 Apr 17;508(7496):397-401. doi: 10.1038/nature13047. Epub 2014 Feb 9.
A committed precursor to innate lymphoid cells.
Constantinides MG, McDonald BD, Verhoef PA, Bendelac A.
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Cell. 2014 Apr 10;157(2):340-56. doi: 10.1016/j.cell.2014.03.030.
Differentiation of Type 1 ILCs from a Common Progenitor to All Helper-like Innate Lymphoid Cell Lineages.
Klose CS, Flach M, Möhle L, Rogell L, Hoyler T, Ebert K, Fabiunke C, Pfeifer D, Sexl V, Fonseca-Pereira D, Domingues RG, Veiga-Fernandes H, Arnold SJ, Busslinger M, Dunay IR, Tanriver Y, Diefenbach A.

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Friday, April 11th, 2014 - Francesca (download presentation file)

Immunity. 2014 Mar 26. pii: S1074-7613(14)00085-5. doi: 10.1016/j.immuni.2014.03.005. [Epub ahead of print]
Segmented Filamentous Bacteria Antigens Presented by Intestinal Dendritic Cells Drive Mucosal Th17 Cell Differentiation.
Goto Y, Panea C, Nakato G, Cebula A, Lee C, Diez MG, Laufer TM, Ignatowicz L, Ivanov II.
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Cell. 2014 Feb 27;156(5):1045-59. doi: 10.1016/j.cell.2014.01.026.
NLRP6 Inflammasome Orchestrates the Colonic Host-Microbial Interface by Regulating Goblet Cell Mucus Secretion.
Wlodarska M, Thaiss CA, Nowarski R, Henao-Mejia J, Zhang JP, Brown EM, Frankel G, Levy M, Katz MN, Philbrick WM, Elinav E, Finlay BB, Flavell RA.

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Friday, April 4th, 2014 - Anna (download presentation file)

Science. 2014 Mar 28;343(6178):1249288. doi: 10.1126/science.1249288. Epub 2014 Mar 13.
Microbiota-Dependent Crosstalk Between Macrophages and ILC3 Promotes Intestinal Homeostasis.
Mortha A, Chudnovskiy A, Hashimoto D, Bogunovic M, Spencer SP, Belkaid Y, Merad M.
PubMed Link - PDF (password) - Supplementary

Nat Immunol. 2014 Apr;15(4):354-64. doi: 10.1038/ni.2830. Epub 2014 Feb 23.
Innate lymphoid cells integrate stromal and immunological signals to enhance antibody production by splenic marginal zone B cells.
Magri G, Miyajima M, Bascones S, Mortha A, Puga I, Cassis L, Barra CM, Comerma L, Chudnovskiy A, Gentile M, Llige D, Cols M, Serrano S, Aróstegui JI, Juan M, Yagüe J, Merad M, Fagarasan S, Cerutti A

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Friday, March 28st, 2014 - Yasu and Sandra (download presentation file 1 2)

Nature. 2014 Mar 6;507(7490):114-7. doi: 10.1038/nature12947. Epub 2014 Jan 26.
Sulphoglycolysis in Escherichia coli K-12 closes a gap in the biogeochemical sulphur cycle.

Denger K, Weiss M, Felux AK, Schneider A, Mayer C, Spiteller D, Huhn T, Cook AM, Schleheck D.
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Nature. 2014 Mar 20;507(7492):366-70. doi: 10.1038/nature12979. Epub 2014 Feb 23.
IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases.
Shen P, Roch T, Lampropoulou V, O'Connor RA, Stervbo U, Hilgenberg E, Ries S, Dang VD, Jaimes Y, Daridon C, Li R, Jouneau L, Boudinot P, Wilantri S, Sakwa I, Miyazaki Y, Leech MD, McPherson RC, Wirtz S, Neurath M, Hoehlig K, Meinl E, Grützkau A, Grün JR, Horn K, Kühl AA, Dörner T, Bar-Or A, Kaufmann SH, Anderton SM, Fillatreau S.

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Friday, March 21st, 2014 - Julien (download presentation file)

PLoS Biol. 2012;10(11):e1001424. doi: 10.1371/journal.pbio.1001424. Epub 2012 Nov 20.
The evolution of mutualism in gut microbiota via host epithelial selection.
Schluter J, Foster KR.

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Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4720-5. doi: 10.1073/pnas.1219247110. Epub 2013 Mar 4.
Host-compound foraging by intestinal microbiota revealed by single-cell stable isotope probing.
Berry D, Stecher B, Schintlmeister A, Reichert J, Brugiroux S, Wild B, Wanek W, Richter A, Rauch I, Decker T, Loy A, Wagner M.

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Friday, March 14th, 2014 - William (download presentation file)

Immunity 40, 1–11, March 20, 2014. doi:10.1016/j.immuni.2014.01.011
Group 2 Innate Lymphoid Cells Are Critical for the Initiation of Adaptive T Helper 2 Cell-Mediated Allergic Lung Inflammation
Timotheus Y.F. Halim, Catherine A. Steer, Laura Mathä, Matthew J. Gold, Itziar Martinez-Gonzalez, Kelly M. McNagny, Andrew N.J. McKenzie, Fumio Takei
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Immunity. 2014 Feb 20;40(2):213-24. doi: 10.1016/j.immuni.2013.12.013. Epub 2014 Feb 6.
Toll-like Receptor and Inflammasome Signals Converge to Amplify the Innate Bactericidal Capacity of T Helper 1 Cells.
O'Donnell H, Pham OH, Li LX, Atif SM, Lee SJ, Ravesloot MM, Stolfi JL, Nuccio SP, Broz P, Monack DM, Baumler AJ, McSorley SJ.

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Friday, March 7th, 2014 - Li Hai (download presentation file)

Immunity. 2014 Feb 20;40(2):262-73. doi: 10.1016/j.immuni.2014.01.003. Epub 2014 Feb 6.
The Cytokine IL-22 Promotes Pathogen Colonization by Suppressing Related Commensal Bacteria.
Behnsen J, Jellbauer S, Wong CP, Edwards RA, George MD, Ouyang W, Raffatellu M.

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Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3074-9. doi: 10.1073/pnas.1315792111. Epub 2014 Feb 3.
Secretory antibodies in breast milk promote long-term intestinal homeostasis by regulating the gut microbiota and host gene expression.
Rogier EW, Frantz AL, Bruno ME, Wedlund L, Cohen DA, Stromberg AJ, Kaetzel CS.

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Friday, February 21st, 2014 - Melissa (download presentation file)

Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):17059-64. doi: 10.1073/pnas.1306070110. Epub 2013 Sep 23.
Genetically dictated change in host mucus carbohydrate landscape exerts a diet-dependent effect on the gut microbiota.
Kashyap PC, Marcobal A, Ursell LK, Smits SA, Sonnenburg ED, Costello EK, Higginbottom SK, Domino SE, Holmes SP, Relman DA, Knight R, Gordon JI, Sonnenburg JL.

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Sci Transl Med. 2014 Jan 22;6(220):220ra11. doi: 10.1126/scitranslmed.3008051.
Identifying gut microbe-host phenotype relationships using combinatorial communities in gnotobiotic mice.
Faith JJ, Ahern PP, Ridaura VK, Cheng J, Gordon JI.

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Friday, February 7th, 2014 - Yasmin (download presentation file)

Science. 2014 Jan 24;343(6169):432-7. doi: 10.1126/science.1247606.
Adaptation of innate lymphoid cells to a micronutrient deficiency promotes type 2 barrier immunity.
Spencer SP, Wilhelm C, Yang Q, Hall JA, Bouladoux N, Boyd A, Nutman TB, Urban JF Jr, Wang J, Ramalingam TR, Bhandoola A, Wynn TA, Belkaid Y.
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J Exp Med. 2014 Jan 13. [Epub ahead of print]
Gata3 drives development of RORγt+ group 3 innate lymphoid cells.
Serafini N, Klein Wolterink RG, Satoh-Takayama N, Xu W, Vosshenrich CA, Hendriks RW, Di Santo JP.
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Friday, January 24th, 2014 - Yasu (download presentation file)

Science. 2013 Sep 6;341(6150):1241214. doi: 10.1126/science.1241214.
Gut microbiota from twins discordant for obesity modulate metabolism in mice.
Ridaura VK, Faith JJ, Rey FE, Cheng J, Duncan AE, Kau AL, Griffin NW, Lombard V, Henrissat B, Bain JR, Muehlbauer MJ, Ilkayeva O, Semenkovich CF, Funai K, Hayashi DK, Lyle BJ, Martini MC, Ursell LK, Clemente JC, Van Treuren W, Walters WA, Knight R, Newgard CB, Heath AC, Gordon JI.

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Nature. 2013 Dec 11. doi: 10.1038/nature12820. [Epub ahead of print]
Diet rapidly and reproducibly alters the human gut microbiome.
David LA, Maurice CF, Carmody RN, Gootenberg DB, Button JE, Wolfe BE, Ling AV, Devlin AS, Varma Y, Fischbach MA, Biddinger SB, Dutton RJ, Turnbaugh PJ.

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Friday, January 10th, 2014 - Mercedes (download presentation file)

Science. 2013 Dec 6;342(6163):1243-6. doi: 10.1126/science.1243364.
Nonredundant function of soluble LTα3 produced by innate lymphoid cells in intestinal homeostasis.
Kruglov AA, Grivennikov SI, Kuprash DV, Winsauer C, Prepens S, Seleznik GM, Eberl G, Littman DR, Heikenwalder M, Tumanov AV, Nedospasov SA.

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J Immunol. 2013 Oct 15;191(8):4383-91. doi: 10.4049/jimmunol.1301228. Epub 2013 Sep 13.
TCF-1 controls ILC2 and NKp46+RORγt+ innate lymphocyte differentiation and protection in intestinal inflammation.
Mielke LA, Groom JR, Rankin LC, Seillet C, Masson F, Putoczki T, Belz GT.

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