Journal Club 2013



Friday, December 20th, 2013 - Stephanie Ganal (download presentation file)

Nature. 2013 Dec 5;504(7478):153-7. doi: 10.1038/nature12687. Epub 2013 Nov 3.
Histone deacetylase 3 coordinates commensal-bacteria-dependent intestinal homeostasis.
Alenghat T, Osborne LC, Saenz SA, Kobuley D, Ziegler CG, Mullican SE, Choi I, Grunberg S, Sinha R, Wynosky-Dolfi M, Snyder A, Giacomin PR, Joyce KL, Hoang TB, Bewtra M, Brodsky IE, Sonnenberg GF, Bushman FD, Won KJ, Lazar MA, Artis D.

PubMed Link - PDF (password) - supplementary material 

Cell. 2013 Dec 3. pii: S0092-8674(13)01473-6. doi: 10.1016/j.cell.2013.11.024. [Epub ahead of print]
Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders.
Hsiao EY, McBride SW, Hsien S, Sharon G, Hyde ER, McCue T, Codelli JA, Chow J, Reisman SE, Petrosino JF, Patterson PH, Mazmanian SK.

PubMed Link - PDF (password) - supplementary material

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Friday, December 13th, 2013 - Francesca Ronchi (download presentation file)

Mucosal Immunol. 2013 Nov 27. doi: 10.1038/mi.2013.95. [Epub ahead of print]
NLRC4 expression in intestinal epithelial cells mediates protection against an enteric pathogen.
Nordlander S, Pott J, Maloy KJ.

PubMed Link - PDF (password) - supplementary material 

Mucosal Immunol. 2013 Nov 27. doi: 10.1038/mi.2013.94. [Epub ahead of print]
Nlrp3 activation in the intestinal epithelium protects against a mucosal pathogen.
Song-Zhao GX, Srinivasan N, Pott J, Baban D, Frankel G, Maloy KJ.

PubMed Link - PDF (password) - supplementary material

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Friday, December 6th, 2013 - Sandra Rupp (download presentation file)

Immunity. 2013 Nov 14;39(5):963-75. doi: 10.1016/j.immuni.2013.10.005. Epub 2013 Oct 24.
A Beneficial Role for Immunoglobulin E in Host Defense against Honeybee Venom.
Marichal T, Starkl P, Reber LL, Kalesnikoff J, Oettgen HC, Tsai M, Metz M, Galli SJ.

PubMed Link - PDF (password) - supplementary material 

Immunity. 2013 Nov 14;39(5):976-85. doi: 10.1016/j.immuni.2013.10.006. Epub 2013 Oct 24.
Bee Venom Phospholipase A2 Induces a Primary Type 2 Response that Is Dependent on the Receptor ST2 and Confers Protective Immunity.
Palm NW, Rosenstein RK, Yu S, Schenten DD, Florsheim E, Medzhitov R.

PubMed Link - PDF (password) - supplementary material


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Friday, Novermber 29th, 2013 - Li Hai (download presentation file)

Nature. 2013 Nov 20. doi: 10.1038/nature12729. [Epub ahead of print]
Antibacterial membrane attack by a pore-forming intestinal C-type lectin.
Mukherjee S, Zheng H, Derebe MG, Callenberg KM, Partch CL, Rollins D, Propheter DC, Rizo J, Grabe M, Jiang QX, Hooper LV.
PubMed Link - PDF (password) - supplementary material 

Nature. 2013 Nov 14;503(7475):272-6. doi: 10.1038/nature12599. Epub 2013 Oct 2.
Paneth cells as a site of origin for intestinal inflammation.
Adolph TE, Tomczak MF, Niederreiter L, Ko HJ, Böck J, Martinez-Naves E, Glickman JN, Tschurtschenthaler M, Hartwig J, Hosomi S, Flak MB, Cusick JL, Kohno K, Iwawaki T, Billmann-Born S, Raine T, Bharti R, Lucius R, Kweon MN, Marciniak SJ, Choi A, Hagen SJ, Schreiber S, Rosenstiel P, Kaser A, Blumberg RS.
PubMed Link - PDF (password) - supplementary material

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Friday, Novermber 22nd, 2013 - William (download presentation file)

Nature. 2013 Nov 13. doi: 10.1038/nature12726. [Epub ahead of print]
Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation.
Arpaia N, Campbell C, Fan X, Dikiy S, van der Veeken J, Deroos P, Liu H, Cross JR, Pfeffer K, Coffer PJ, Rudensky AY.
PubMed Link - PDF (password) - supplementary material 

Nature. 2013 Nov 13. doi: 10.1038/nature12721. [Epub ahead of print]
Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells.
Furusawa Y, Obata Y, Fukuda S, Endo TA, Nakato G, Takahashi D, Nakanishi Y, Uetake C, Kato K, Kato T, Takahashi M, Fukuda NN, Murakami S, Miyauchi E, Hino S, Atarashi K, Onawa S, Fujimura Y, Lockett T, Clarke JM, Topping DL, Tomita M, Hori S, Ohara O, Morita T, Koseki H, Kikuchi J, Honda K, Hase K, Ohno H.
PubMed Link - PDF (password) - supplementary material

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Friday, Novermber 8th, 2013 - Melissa Lawson (download presentation file)

Nature. 2013 Jul 11;499(7457):219-22. doi: 10.1038/nature12212. Epub 2013 Jun 9.
Antibiotic treatment expands the resistance reservoir and ecological network of the phage metagenome.
Modi SR, Lee HH, Spina CS, Collins JJ.
PubMed Link - PDF (password) - supplementary material 

PLoS One. 2013 Oct 7;8(10):e74957. doi: 10.1371/journal.pone.0074957.
Bacterial community mapping of the mouse gastrointestinal tract.
Gu S, Chen D, Zhang JN, Lv X, Wang K, Duan LP, Nie Y, Wu XL.
PubMed Link - PDF (password) - supplementary material

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Friday, Novermber 1st, 2013 - Yasmin köller (download presentation file)

Nature. 2013 Oct 10;502(7470):245-8. doi: 10.1038/nature12526. Epub 2013 Sep 15.
Type 2 innate lymphoid cells control eosinophil homeostasis.
Nussbaum JC, Van Dyken SJ, von Moltke J, Cheng LE, Mohapatra A, Molofsky AB, Thornton EE, Krummel MF, Chawla A, Liang HE, Locksley RM.
PubMed Link - PDF (password) - supplementary material 

Immunity. 2013 Oct 17;39(4):744-57. doi: 10.1016/j.immuni.2013.07.020.
Th9 Cells Drive Host Immunity against Gastrointestinal Worm Infection.
Licona-Limón P, Henao-Mejia J, Temann AU, Gagliani N, Licona-Limón I, Ishigame H, Hao L, Herbert DR, Flavell RA.
PubMed Link - PDF (password) - supplementary material

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Friday, October 11th, 2013 - Stephanie Ganal (download presentation file)

Immunity. 2013 Sep 19;39(3):560-72. doi: 10.1016/j.immuni.2013.08.005. Epub 2013 Aug 29.
Extrathymic Aire-Expressing Cells Are a Distinct Bone Marrow-Derived Population that Induce Functional Inactivation of CD4(+) T Cells.
Gardner JM, Metzger TC, McMahon EJ, Au-Yeung BB, Krawisz AK, Lu W, Price JD, Johannes KP, Satpathy AT, Murphy KM, Tarbell KV, Weiss A, Anderson MS.
PubMed Link - PDF (password) - supplementary material 

J Exp Med. 2013 Sep 23;210(10):2011-24. doi: 10.1084/jem.20130728. Epub 2013 Sep 9.
Intestinal lamina propria dendritic cells maintain T cell homeostasis but do not affect commensalism.
Welty NE, Staley C, Ghilardi N, Sadowsky MJ, Igyártó BZ, Kaplan DH.
PubMed Link - PDF (password) - supplementary material

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Friday, October 4th, 2013 - Mercedes Gomez (download presentation file)

Science. 2013 Sep 26.
Mucus Enhances Gut Homeostasis and Oral Tolerance by Delivering Immunoregulatory Signals.
Shan M, Gentile M, Yeiser JR, Walland AC, Bornstein VU, Chen K, He B, Cassis L, Bigas A, Cols M, Comerma L, Huang B, Blander JM, Xiong H, Mayer L, Berin C, Augenlicht LH, Velcich A, Cerutti A.
PubMed Link - PDF (password) - supplementary material - Movie S1 - Movie S2 (download movies and watch with VLC)

Nat Immunol. 2013 Sep;14(9):937-48. doi: 10.1038/ni.2679. Epub 2013 Aug 4.
Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens.
Satpathy AT, Briseño CG, Lee JS, Ng D, Manieri NA, Kc W, Wu X, Thomas SR, Lee WL, Turkoz M, McDonald KG, Meredith MM, Song C, Guidos CJ, Newberry RD, Ouyang W, Murphy TL, Stappenbeck TS, Gommerman JL, Nussenzweig MC, Colonna M, Kopan R, Murphy KM.
PubMed Link - PDF (password) - supplementary material

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Friday, September 27th, 2013 - Francesca Ronchi (download presentation file)

Cell Host Microbe. 2013 Sep 11;14(3):318-28. doi: 10.1016/j.chom.2013.08.003.
Intraluminal Containment of Commensal Outgrowth in the Gut during Infection-Induced Dysbiosis.
Molloy MJ, Grainger JR, Bouladoux N, Hand TW, Koo LY, Naik S, Quinones M, Dzutsev AK, Gao JL, Trinchieri G, Murphy PM, Belkaid Y.
PubMed Link - PDF (password) - supplementary material

Immunity. 2013 Jun 27;38(6):1154-63. doi: 10.1016/j.immuni.2013.05.015.
Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation.
Yan Y, Jiang W, Spinetti T, Tardivel A, Castillo R, Bourquin C, Guarda G, Tian Z, Tschopp J, Zhou R.
PubMed Link - PDF (password) - supplementary material

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Friday, September 20th, 2013 - Sandra Rupp (download presentation file)

Nature. 2013 Sep 5;501(7465):112-5. doi: 10.1038/nature12496. Epub 2013 Aug 21.
Microbial colonization influences early B-lineage development in the gut lamina propria.
Wesemann DR, Portuguese AJ, Meyers RM, Gallagher MP, Cluff-Jones K, Magee JM, Panchakshari RA, Rodig SJ, Kepler TB, Alt FW.
PubMed Link - PDF (password) - supplementary material

J Immunol. 2013 Aug 30. [Epub ahead of print]
TLR4 Signaling Shapes B Cell Dynamics via MyD88-Dependent Pathways and Rac GTPases.
Barrio L, Saez de Guinoa J, Carrasco YR.
PubMed Link - PDF (password) - supplementary material - sv1 - sv2 - sv3 - sv4 - sv5

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Friday, September 6th, 2013 - Li Hai (download presentation file)

Nature. 2013 Aug 18. doi: 10.1038/nature12447.
Bacterial colonization factors control specificity and stability of the gut microbiota.
Lee SM, Donaldson GP, Mikulski Z, Boyajian S, Ley K, Mazmanian SK.
PubMed Link - PDF (password) - supplementary material

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Friday, August 23rd, 2013 - William Kwong Chung (download presentation file)

Immunity. 2013 May 23;38(5):998-1012. doi: 10.1016/j.immuni.2013.01.013. Epub 2013 May 16.
An inherently bifunctional subset of Foxp3+ T helper cells is controlled by the transcription factor eos.
Sharma MD, Huang L, Choi JH, Lee EJ, Wilson JM, Lemos H, Pan F, Blazar BR, Pardoll DM, Mellor AL, Shi H, Munn DH.
PubMed Link - PDF (password)supplementary material

Nature. 2013 Jun 27;498(7455):506-10. doi: 10.1038/nature12199. Epub 2013 Jun 2.
BACH2 represses effector programs to stabilize T(reg)-mediated immune homeostasis.
Roychoudhuri R, Hirahara K, Mousavi K, Clever D, Klebanoff CA, Bonelli M, Sciumè G, Zare H, Vahedi G, Dema B, Yu Z, Liu H, Takahashi H, Rao M, Muranski P, Crompton JG, Punkosdy G, Bedognetti D, Wang E, Hoffmann V, Rivera J, Marincola FM, Nakamura A, Sartorelli V, Kanno Y, Gattinoni L, Muto A, Igarashi K, O'Shea JJ, Restifo NP.
PubMed Link - PDF (password)supplementary material

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Friday, August 16th, 2013 - Yasuhiro Uchimura (download presentation file)

Nature. 2013 Jul 4;499(7456):97-101. doi: 10.1038/nature12347. Epub 2013 Jun 26.
Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome.
Yoshimoto S, Loo TM, Atarashi K, Kanda H, Sato S, Oyadomari S, Iwakura Y, Oshima K, Morita H, Hattori M, Honda K, Ishikawa Y, Hara E, Ohtani N.
PubMed Link - PDF (password)supplementary material

Nature. 2013 Jul 25;499(7459):485-90. doi: 10.1038/nature12297. Epub 2013 Jun 30.
mTORC1 couples immune signals and metabolic programming to establish T(reg)-cell function.
Zeng H, Yang K, Cloer C, Neale G, Vogel P, Chi H.
PubMed Link - PDF (password)supplementary material

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Friday, August 9th, 2013 - Melissa Lawson (download presentation file)

Cell Host Microbe. 2013 Jun 12;13(6):723-34. doi: 10.1016/j.chom.2013.05.004.
Intestinal epithelial autophagy is essential for host defense against invasive bacteria.
Benjamin JL, Sumpter R Jr, Levine B, Hooper LV.
PubMed Link - PDF (password)supplementary material

Nature. 2013 Aug 8;500(7461):232-6. doi: 10.1038/nature12331. Epub 2013 Jul 10.
Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota.
Atarashi K, Tanoue T, Oshima K, Suda W, Nagano Y, Nishikawa H, Fukuda S, Saito T, Narushima S, Hase K, Kim S, Fritz JV, Wilmes P, Ueha S, Matsushima K, Ohno H, Olle B, Sakaguchi S, Taniguchi T, Morita H, Hattori M, Honda K.
PubMed Link - PDF (password)supplementary material

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Friday, July 26th, 2013 - Yasmin Köller (download presentation file)

Immunity. 2013 Jun 27;38(6):1211-22. doi: 10.1016/j.immuni.2013.05.012. Epub 2013 Jun 20.
Dendritic Cell Expression of the Signaling Molecule TRAF6 Is Critical for Gut Microbiota-Dependent Immune Tolerance.
Han D, Walsh MC, Cejas PJ, Dang NN, Kim YF, Kim J, Charrier-Hisamuddin L, Chau L, Zhang Q, Bittinger K, Bushman FD, Turka LA, Shen H, Reizis B, Defranco AL, Wu GD, Choi Y.
PubMed Link - PDF (password) - supplementary material

Science. 2013 Jul 4. [Epub ahead of print]
The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis.
Smith PM, Howitt MR, Panikov N, Michaud M, Gallini CA, Bohlooly-Y M, Glickman JN, Garrett WS.
Source
PubMed LinkPDF (password) - supplementary material

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Friday, July 19th, 2013 - Thomas Schaffer (download presentation file)

Nat Immunol. 2013 May 19;14(7):741-8. doi: 10.1038/ni.2610. Epub 2013 May 19.
T cell regulation mediated by interaction of soluble CD52 with the inhibitory receptor Siglec-10.
Bandala-Sanchez E, Zhang Y, Reinwald S, Dromey JA, Lee BH, Qian J, Böhmer RM, Harrison LC.
PubMed Link - PDF (password)supplementary material

Sci Transl Med. 2013 Jul 10;5(193):193ra91. doi: 10.1126/scitranslmed.3006438.
Dysbiosis of the Gut Microbiota Is Associated with HIV Disease Progression and Tryptophan Catabolism.
Vujkovic-Cvijin I, Dunham RM, Iwai S, Maher MC, Albright RG, Broadhurst MJ, Hernandez RD, Lederman MM, Huang Y, Somsouk M, Deeks SG, Hunt PW, Lynch SV, McCune JM.
PubMed Link - PDF (password)supplementary material

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Friday, June 28th, 2013 - Li Hai (download presentation file)

Proc Natl Acad Sci U S A. 2013 Jun 18. [Epub ahead of print]
IL-22-producing neutrophils contribute to antimicrobial defense and restitution of colonic epithelial integrity during colitis.
Zindl CL, Lai JF, Lee YK, Maynard CL, Harbour SN, Ouyang W, Chaplin DD, Weaver CT.
PubMed LinkPDF (password)

J Exp Med. 2013 Jun 3;210(6):1117-24. doi: 10.1084/jem.20121588. Epub 2013 May 20.
Retinoic acid expression associates with enhanced IL-22 production by γδ T cells and innate lymphoid cells and attenuation of intestinal inflammation.
Mielke LA, Jones SA, Raverdeau M, Higgs R, Stefanska A, Groom JR, Misiak A, Dungan LS, Sutton CE, Streubel G, Bracken AP, Mills KH.
PubMed LinkPDF (password)

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Friday, June 21st, 2013 - Francesca (download presentation file)

Immunity. 2013 Jan 24;38(1):79-91. doi: 10.1016/j.immuni.2012.12.001. Epub 2012 Dec 27.
Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis.
Yona S, Kim KW, Wolf Y, Mildner A, Varol D, Breker M, Strauss-Ayali D, Viukov S, Guilliams M, Misharin A, Hume DA, Perlman H, Malissen B, Zelzer E, Jung S.
PubMed Link - PDF (password) - supplementary material - Erratum (corrected Figures)

Immunity. 2013 May 23;38(5):970-83. doi: 10.1016/j.immuni.2013.04.011.
IRF4 Transcription Factor-Dependent CD11b(+) Dendritic Cells in Human and Mouse Control Mucosal IL-17 Cytokine Responses.
Schlitzer A, McGovern N, Teo P, Zelante T, Atarashi K, Low D, Ho AW, See P, Shin A, Wasan PS, Hoeffel G, Malleret B, Heiseke A, Chew S, Jardine L, Purvis HA, Hilkens CM, Tam J, Poidinger M, Stanley ER, Krug AB, Renia L, Sivasankar B, Ng LG, Collin M, Ricciardi-Castagnoli P, Honda K, Haniffa M, Ginhoux F.
PubMed Link - PDF (password) - supplementary material

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Friday, June 7th, 2013 - Julia Cahenzli (download presentation file)

Science. 2013 Apr 25. [Epub ahead of print]
Role of Tissue Protection in Lethal Respiratory Viral-Bacterial Coinfection.
Jamieson AM, Pasman L, Yu S, Gamradt P, Homer RJ, Decker T, Medzhitov R.
PubMed Link - PDF (password) - supplementary material

Nat Med. 2013 May 26. doi: 10.1038/nm.3189. [Epub ahead of print]
Inflammatory monocytes regulate pathologic responses to commensals during acute gastrointestinal infection.
Grainger JR, Wohlfert EA, Fuss IJ, Bouladoux N, Askenase MH, Legrand F, Koo LY, Brenchley JM, Fraser ID, Belkaid Y.
PubMed Link - PDF (password) - supplementary material

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Friday, May 31th, 2013 - William Kwong (download presentation file)

Science. 2013 May 9; Sciencexpress Epub ahead of print.
GPR15-Mediated Homing Controls Immune Homeostasis in the Large Intestine Mucosa.
Sangwon V. Kim, Wenkai V. Xiang, Changsoo Kwak, Yi Yang, Xiyao W. Lin, Mitsuhiko Ota, Umut Sarpel, Daniel B. Rifkin, Ruliang Xu, and Dan R. Littman
PubMed Link - PDF (password) - supplementary material

Nature. 2013 May 22; Epub ahead of print.
Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria.
Matthew R. Hepworth, Laurel A. Monticelli, Thomas C. Fung, Carly G. K. Ziegler, Stephanie Grunberg, Rohini Sinha, Adriana R. Mantegazza, Hak-Ling Ma, Alison Crawford,
Jill M. Angelosanto, E. John Wherry, Pandelakis A. Koni, Frederic D. Bushman, Charles O. Elson, Gérard Eberl, David Artis & Gregory F. Sonnenberg
PubMed Link - PDF (password) - supplementary material

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Friday, May 24th, 2013 - Yasu Uchimura (download presentation file)

Science. 2012 May 4;336(6081):601-4. doi: 10.1126/science.1216882.
Multidimensional optimality of microbial metabolism.
Schuetz R, Zamboni N, Zampieri M, Heinemann M, Sauer U.
PubMed Link - PDF (password) - supplementary material

Nat Biotechnol. 2013 Apr;31(4):357-61. doi: 10.1038/nbt.2489. Epub 2013 Mar 3.
Systematic identification of allosteric protein-metabolite interactions that control enzyme activity in vivo.
Link H, Kochanowski K, Sauer U.
PubMed LinkPDF (password) - supplementary material - supplementary material 2

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Friday, May 17th, 2013 - Sandra Rupp (download presentation file)

Nat Immunol. 2013 May;14(5):514-22. doi: 10.1038/ni.2569. Epub 2013 Apr 7.
Trypanosoma cruzi trans-sialidase initiates a program independent of the transcription factors RORγt and Ahr that leads to IL-17 production by activated B cells.
Bermejo DA, Jackson SW, Gorosito-Serran M, Acosta-Rodriguez EV, Amezcua-Vesely MC, Sather BD, Singh AK, Khim S, Mucci J, Liggitt D, Campetella O, Oukka M, Gruppi A, Rawlings DJ.
PubMed LinkPDF (password) - supplementary material

J Immunol. 2013 May 15;190(10):4923-7. doi: 10.4049/jimmunol.1300350. Epub 2013 Apr 8.
Cutting edge: macrophages are required for localization of antigen-activated B cells to the follicular perimeter and the subsequent germinal center response.
Nikbakht N, Shen S, Manser T.
PubMed LinkPDF (password)supplementary material

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Friday, May 10th, 2013 - Yasmin Köller (download presentation file)

Nature. 2013 Apr 25;496(7446):523-7. doi: 10.1038/nature12058.
Follicular T-helper cell recruitment governed by bystander B cells and ICOS-driven motility.
Xu H, Li X, Liu D, Li J, Zhang X, Chen X, Hou S, Peng L, Xu C, Liu W, Zhang L, Qi H.
PubMed LinkPDF (password) - supplementary material - Videos

Nat Immunol. 2013 Apr 21. doi: 10.1038/ni.2584. [Epub ahead of print]
Cutaneous immunosurveillance and regulation of inflammation by group 2 innate lymphoid cells.
Roediger B, Kyle R, Yip KH, Sumaria N, Guy TV, Kim BS, Mitchell AJ, Tay SS, Jain R, Forbes-Blom E, Chen X, Tong PL, Bolton HA, Artis D, Paul WE, de St Groth BF, Grimbaldeston MA, Le Gros G, Weninger W.
PubMed LinkPDF (password) - supplementray material - Videos 1 2 3 4 5 6 7 8 9 10 11

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Friday, May 3rd, 2013 - Melissa Lawson (download presentation file)

Cell. 2013 Feb 14;152(4):884-94. doi: 10.1016/j.cell.2013.01.042.
Tit-for-tat: type VI secretion system counterattack during bacterial cell-cell interactions.
Basler M, Ho BT, Mekalanos JJ.
PubMed LinkPDF (password) - supplementary material

Nature. 2013 Apr 25;496(7446):508-12. doi: 10.1038/nature12074. Epub 2013 Apr 3.
Diverse type VI secretion phospholipases are functionally plastic antibacterial effectors.
Russell AB, LeRoux M, Hathazi K, Agnello DM, Ishikawa T, Wiggins PA, Wai SN, Mougous JD.
PubMed LinkPDF (password)

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Friday, April 12th, 2013 - Li Hai (download presentation file)

Nat Immunol. 2013 Apr;14(4):372-9. doi: 10.1038/ni.2552. Epub 2013 Mar 10.
Plasticity of TH17 cells in Peyer's patches is responsible for the induction of T cell-dependent IgA responses.
Hirota K, Turner JE, Villa M, Duarte JH, Demengeot J, Steinmetz OM, Stockinger B.
PubMed LinkPDF (password) - supplementary material

Nat Immunol. 2013 Mar;14(3):271-80. doi: 10.1038/ni.2518. Epub 2013 Jan 20.
Mutual expression of the transcription factors Runx3 and ThPOK regulates intestinal CD4⁺ T cell immunity.
Reis BS, Rogoz A, Costa-Pinto FA, Taniuchi I, Mucida D.
PubMed LinkPDF (password) - supplementary material

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Friday, April 5th, 2013 - Markus Geuking (download presentation file)

Nature. 2013 Mar 6. doi: 10.1038/nature11868.
Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells.
Kleinewietfeld M, Manzel A, Titze J, Kvakan H, Yosef N, Linker RA, Muller DN, Hafler DA.
PubMed LinkPDF (password) - supplementary material

Nature. 2013 Mar 6. doi: 10.1038/nature11984. [Epub ahead of print]
Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1.
Wu C, Yosef N, Thalhamer T, Zhu C, Xiao S, Kishi Y, Regev A, Kuchroo VK.
PubMed LinkPDF (password) - supplementary material 1 - supplementary material 2 - supplementary material 3

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Friday, March 15th, 2013 - Francesca Ronchi (download presentation file)

Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9601-6. doi: 10.1073/pnas.1100981108. Epub 2011 May 18.
Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injury.
Normand S, Delanoye-Crespin A, Bressenot A, Huot L, Grandjean T, Peyrin-Biroulet L, Lemoine Y, Hot D, Chamaillard M.
PubMed LinkPDF (password) - supplementary material

Nature. 2012 Aug 16;488(7411):389-93. doi: 10.1038/nature11250.
NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens.
Anand PK, Malireddi RK, Lukens JR, Vogel P, Bertin J, Lamkanfi M, Kanneganti TD.
PubMed LinkPDF (password) - supplementary material

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Friday, February 22th, 2013 - William Kwong Chung (download presentation file)

Nat Immunol. 2012 Dec 23;14(2):162-71. doi: 10.1038/ni.2499. Epub 2012 Dec 23.
Absence of signaling into CD4(+) cells via C3aR and C5aR enables autoinductive TGF-β1 signaling and induction of Foxp3(+) regulatory T cells.
Strainic MG, Shevach EM, An F, Lin F, Medof ME.
PubMed LinkPDF (password) - supplementary material

J Exp Med. 2013 Feb 11;210(2):257-68. doi: 10.1084/jem.20121525. Epub 2013 Feb 4.
Signaling through C5a receptor and C3a receptor diminishes function of murine natural regulatory T cells.
Kwan WH, van der Touw W, Paz-Artal E, Li MO, Heeger PS.
PubMed LinkPDF (password)

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Friday, February 15th, 2013 - Yasmin Köller (download presentation file)

Science. 2013 Feb 8;339(6120):708-11. doi: 10.1126/science.1232467.
Host-derived nitrate boosts growth of E. coli in the inflamed gut.
Winter SE, Winter MG, Xavier MN, Thiennimitr P, Poon V, Keestra AM, Laughlin RC, Gomez G, Wu J, Lawhon SD, Popova IE, Parikh SJ, Adams LG, Tsolis RM, Stewart VJ, Bäumler AJ.
PubMed Link - PDF (password) - supplementary material

Sci Transl Med. 2013 Jan 30;5(170):170ra16. doi: 10.1126/scitranslmed.3005374.
TSLP Elicits IL-33-Independent Innate Lymphoid Cell Responses to Promote Skin Inflammation.
Kim BS, Siracusa MC, Saenz SA, Noti M, Monticelli LA, Sonnenberg GF, Hepworth MR, Van Voorhees AS, Comeau MR, Artis D.
PubMed Link - PDF (password)

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Friday, February 8th, 2013 - Sandra Rupp (download presentation file)

Journal of Immunology, (2013). 190(3), 987–996. doi:10.4049/jimmunol.1202227
The Mouse IgM Fc Receptor, FCMR, Promotes B Cell Development and Modulates Antigen-Driven Immune Responses.
Choi, S. C., Wang, H., Tian, L., Murakami, Y., Shin, D. M., Borrego, F., et al.
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Nature, (2013) 493(7434), 684–688. doi:10.1038/nature11738
Visualization of splenic marginal zone B-cell shuttling and follicular B-cell egress.
Arnon, T. I., Horton, R. M., Grigorova, I. L., & Cyster, J. G.
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Friday, February 1st, 2013 - Mercedes Gomez (download presentation file)

Nature. 2013 Jan 13. doi: 10.1038/nature11809.
Microbiota restricts trafficking of bacteria to mesenteric lymph nodes by CX(3)CR1(hi) cells.
Diehl GE, Longman RS, Zhang JX, Breart B, Galan C, Cuesta A, Schwab SR, Littman DR.
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Nature. 2013 Jan 16. doi: 10.1038/nature11813. [Epub ahead of print]
A T-bet gradient controls the fate and function of CCR6(-)RORγt(+) innate lymphoid cells.
Klose CS, Kiss EA, Schwierzeck V, Ebert K, Hoyler T, d'Hargues Y, Göppert N, Croxford AL, Waisman A, Tanriver Y, Diefenbach A.
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Friday, January 25th, 2013 - Yasuhiro Uchimura (download presentation file)

Nature,  (2012) 491(7426), 717–723. doi:10.1038/nature11605
MR1 presents microbial vitamin B metabolites to MAIT cells.
Kjer-Nielsen, L., Patel, O., Corbett, A. J., Le Nours, J., Meehan, B., Liu, L., et al.
PubMed Link - PDF (password) - supplementary material 

Nature, (2012) 487(7408), 477–481. doi:10.1038/nature11228
ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation.
Hashimoto, T., Perlot, T., Rehman, A., Trichereau, J., Ishiguro, H., Paolino, M., et al
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Friday, January 18th, 2013 - Li Hai (download presentation file)

J Exp Med. 2012 Dec 17;209(13):2367-81. doi: 10.1084/jem.20120325. Epub 2012 Dec 10.
Antibody orientation at bacterial surfaces is related to invasive infection.
Nordenfelt P, Waldemarson S, Linder A, Mörgelin M, Karlsson C, Malmström J, Björck L.
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Nat Immunol. 2013 Feb;14(2):136-42. doi: 10.1038/ni.2508. Epub 2012 Dec 23.
Parasite-induced T(H)1 cells and intestinal dysbiosis cooperate in IFN-γ-dependent elimination of Paneth cells.
Raetz M, Hwang SH, Wilhelm CL, Kirkland D, Benson A, Sturge CR, Mirpuri J, Vaishnava S, Hou B, Defranco AL, Gilpin CJ, Hooper LV, Yarovinsky F.
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Friday, January 11th, 2013 - Melissa Lawson (download presentation file)

Nature. 2012 Dec 6;492(7427):113-7. doi: 10.1038/nature11623. Epub 2012 Nov 18.
Fucose sensing regulates bacterial intestinal colonization.
Pacheco AR, Curtis MM, Ritchie JM, Munera D, Waldor MK, Moreira CG, Sperandio V.
PubMed Link - PDF (password) - supplementary material

Infect Immun. 2012 May;80(5):1716-27. doi: 10.1128/IAI.06193-11. Epub 2012 Mar 5.
The streptomycin-treated mouse intestine selects Escherichia coli envZ missense mutants that interact with dense and diverse intestinal microbiota.
Leatham-Jensen MP, Frimodt-Møller J, Adediran J, Mokszycki ME, Banner ME, Caughron JE, Krogfelt KA, Conway T, Cohen PS.
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