Journal Club 2012




December 2012

Friday, December 21, 2012 - Sandra Rupp (download presentation file)

J Immunol. 2012 Dec 15;189(12):5503-7. doi: 10.4049/jimmunol.1201413. Epub 2012 Nov 12.
Cutting Edge: B cells are essential for protective immunity against Salmonella independent of antibody secretion.
Nanton MR, Way SS, Shlomchik MJ, McSorley SJ.
PubMed Link - PDF (password)

Immunity. 2012 Nov 16;37(5):893-904. doi: 10.1016/j.immuni.2012.07.017. Epub 2012 Nov 8.
Elimination of germinal-center-derived self-reactive B cells is governed by the location and concentration of self-antigen.
Chan TD, Wood K, Hermes JR, Butt D, Jolly CJ, Basten A, Brink R.
PubMed Link - PDF (password)


Friday, December 14, 2012 - Yasmin Köller (download presentation file)

Immunity. 2012 Nov 16;37(5):930-46. doi: 10.1016/j.immuni.2012.07.016. Epub 2012 Nov 1.
The short isoform of the CEACAM1 receptor in intestinal T cells regulates mucosal immunity and homeostasis via Tfh cell induction.
Chen L, Chen Z, Baker K, Halvorsen EM, da Cunha AP, Flak MB, Gerber G, Huang YH, Hosomi S, Arthur JC, Dery KJ, Nagaishi T, Beauchemin N, Holmes KV, Ho JW, Shively JE, Jobin C, Onderdonk AB, Bry L, Weiner HL, Higgins DE, Blumberg RS.
PubMed Link - PDF (password)

Immunity. 2012 Dec 14;37(6):1061-75. doi: 10.1016/j.immuni.2012.08.024. Epub 2012 Nov 29.
Th22 cells are an important source of IL-22 for host protection against enteropathogenic bacteria.
Basu R, O'Quinn DB, Silberger DJ, Schoeb TR, Fouser L, Ouyang W, Hatton RD, Weaver CT.
PubMed Link - PDF (password)

November 2012

Friday, November 30, 2012 - William Kwong Chung (download presentation file)

Nature. 2012 Nov 22;491(7425):554-9. doi: 10.1038/nature11581. Epub 2012 Nov 7.
Novel Foxo1-dependent transcriptional programs control T(reg) cell function.
Ouyang W, Liao W, Luo CT, Yin N, Huse M, Kim MV, Peng M, Chan P, Ma Q, Mo Y, Meijer D, Zhao K, Rudensky AY, Atwal G, Zhang MQ, Li MO.
PubMed Link - PDF (password)

Science. 2012 Oct 26;338(6106):532-6. doi: 10.1126/science.1227049.
Regulatory T cells increase the avidity of primary CD8+ T cell responses and promote memory.
Pace L, Tempez A, Arnold-Schrauf C, Lemaitre F, Bousso P, Fetler L, Sparwasser T, Amigorena S.
PubMed Link - PDF (password)


Friday, November 16, 2012 - Markus Geuking (download presentation file)

Immunity. 2012 Oct 19;37(4):709-20. doi: 10.1016/j.immuni.2012.06.021.
T cell affinity regulates asymmetric division, effector cell differentiation, and tissue pathology.
King CG, Koehli S, Hausmann B, Schmaler M, Zehn D, Palmer E.
PubMed Link - PDF (password)

Immunity. 2012 Oct 19;37(4):735-46. doi: 10.1016/j.immuni.2012.08.008. Epub 2012 Sep 27.
Subsets of nonclonal neighboring CD4+ T cells specifically regulate the frequency of individual antigen-reactive T cells.
Singh NJ, Bando JK, Schwartz RH.
PubMed Link - PDF (password)


Friday, November 02, 2012 - Melissa Lawson (download presentation file)

Cell Host Microbe. 2012 Aug 16;12(2):139-52. doi: 10.1016/j.chom.2012.07.004. Epub 2012 Aug 2.
Transient inability to manage proteobacteria promotes chronic gut inflammation in TLR5-deficient mice.
Carvalho FA, Koren O, Goodrich JK, Johansson ME, Nalbantoglu I, Aitken JD, Su Y, Chassaing B, Walters WA, González A, Clemente JC, Cullender TC, Barnich N, Darfeuille-Michaud A, Vijay-Kumar M, Knight R, Ley RE, Gewirtz AT.
PubMed Link - PDF (password)

Gastroenterology. 2012 Oct;143(4):1006-16.e4. doi: 10.1053/j.gastro.2012.06.034. Epub 2012 Jun 23.
Gut microbial products regulate murine gastrointestinal motility via Toll-like receptor 4 signaling.
Anitha M, Vijay-Kumar M, Sitaraman SV, Gewirtz AT, Srinivasan S.
PubMed Link - PDF (password)

October 2012

Friday, October 26, 2012 - Li Ha (download presentation file)

Immunity. 2012 Oct 19;37(4):674-84. doi: 10.1016/j.immuni.2012.09.008. Epub 2012 Oct 11.
The transcription factor T-bet regulates intestinal inflammation mediated by interleukin-7 receptor+ innate lymphoid cells.
Powell N, Walker AW, Stolarczyk E, Canavan JB, Gökmen MR, Marks E, Jackson I, Hashim A, Curtis MA, Jenner RG, Howard JK, Parkhill J, MacDonald TT, Lord GM.
PubMed Link - PDF (password)

Nat Immunol. 2012 Nov;13(11):1101-9. doi: 10.1038/ni.2423. Epub 2012 Sep 30.
The kinase TBK1 controls IgA class switching by negatively regulating noncanonical NF-κB signaling.
Jin J, Xiao Y, Chang JH, Yu J, Hu H, Starr R, Brittain GC, Chang M, Cheng X, Sun SC.
PubMed Link - PDF (password)


Friday, October 12, 2012 - Julia Cahenzli (download presentation file)

Immunity. 2012 Oct 19;37(4):660-73. doi: 10.1016/j.immuni.2012.09.007. Epub 2012 Oct 4.
The transcription factor T-bet is induced by multiple pathways and prevents an endogenous Th2 cell program during Th1 cell responses.
Zhu J, Jankovic D, Oler AJ, Wei G, Sharma S, Hu G, Guo L, Yagi R, Yamane H, Punkosdy G, Feigenbaum L, Zhao K, Paul WE.
PubMed Link - PDF (password)

Immunity. 2012 Sep 21;37(3):524-34. doi: 10.1016/j.immuni.2012.06.011. Epub 2012 Sep 6.
γδ T cells recognize a microbial encoded B cell antigen to initiate a rapid antigen-specific interleukin-17 response.
Zeng X, Wei YL, Huang J, Newell EW, Yu H, Kidd BA, Kuhns MS, Waters RW, Davis MM, Weaver CT, Chien YH.
PubMed Link - PDF (password)


Friday, October 05, 2012 - Yasmin Köller (download presentation file)

Nature. 2012 Oct 4;490(7418):102-6. doi: 10.1038/nature11462. Epub 2012 Sep 26.
Pregnancy imprints regulatory memory that sustains anergy to fetal antigen.
Rowe JH, Ertelt JM, Xin L, Way SS.
PubMed Link - PDF (password)

J Immunol. 2012 Nov 1;189(9):4666-73. doi: 10.4049/jimmunol.1200955. Epub 2012 Sep 19.
Th17 cells upregulate polymeric Ig receptor and intestinal IgA and contribute to intestinal homeostasis.
Cao AT, Yao S, Gong B, Elson CO, Cong Y.
PubMed Link - PDF (password)

September 2012

Friday, September 28, 2012 - William Kwong Chung (download presentation file)

Immunity. 2012 Aug 24;37(2):264-75. doi: 10.1016/j.immuni.2012.05.025. Epub 2012 Aug 16.
Dendritic cells ameliorate autoimmunity in the CNS by controlling the homeostasis of PD-1 receptor(+) regulatory T cells.
Yogev N, Frommer F, Lukas D, Kautz-Neu K, Karram K, Ielo D, von Stebut E, Probst HC, van den Broek M, Riethmacher D, Birnberg T, Blank T, Reizis B, Korn T, Wiendl H, Jung S, Prinz M, Kurschus FC, Waisman A.
PubMed Link - PDF (password)

J Exp Med. 2012 Aug 27;209(9):1529-35. doi: 10.1084/jem.20112646. Epub 2012 Aug 20.
Smad3 binding to the foxp3 enhancer is dispensable for the development of regulatory T cells with the exception of the gut.
Schlenner SM, Weigmann B, Ruan Q, Chen Y, von Boehmer H.
PubMed Link - PDF (password)


Friday, September 21, 2012 - Markus Geuking (download presentation file)

J Exp Med. 2012 Sep 24;209(10):1723-42, S1. Epub 2012 Sep 10.
Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells.
Weiss JM, Bilate AM, Gobert M, Ding Y, Curotto de Lafaille MA, Parkhurst CN, Xiong H, Dolpady J, Frey AB, Ruocco MG, Yang Y, Floess S, Huehn J, Oh S, Li MO, Niec RE, Rudensky AY, Dustin ML, Littman DR, Lafaille JJ
PubMed Link - PDF (password)

J Exp Med. 2012 Sep 24;209(10):1713-22, S1-19
Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo.
Yadav M, Louvet C, Davini D, Gardner JM, Martinez-Llordella M, Bailey-Bucktrout S, Anthony BA, Sverdrup FM, Head R, Kuster DJ, Ruminski P, Weiss D, Von Schack D, Bluestone JA.
PubMed Link - PDF (password)


Friday, September 14, 2012 - Li Hai (download presentation file)

Nature. 2012 Aug 30;488(7413):621-6. doi: 10.1038/nature11400.
Antibiotics in early life alter the murine colonic microbiome and adiposity.
Cho I, Yamanishi S, Cox L, Methé BA, Zavadil J, Li K, Gao Z, Mahana D, Raju K, Teitler I, Li H, Alekseyenko AV, Blaser MJ.
PubMed Link - PDF (password)

Nat Immunol. 2012 Oct;13(10):947-53. doi: 10.1038/ni.2403. Epub 2012 Aug 26.
Lymphotoxin regulates commensal responses to enable diet-induced obesity.
Upadhyay V, Poroyko V, Kim TJ, Devkota S, Fu S, Liu D, Tumanov AV, Koroleva EP, Deng L, Nagler C, Chang EB, Tang H, Fu YX.
PubMed Link - PDF (password)


Friday, September 3, 2012 - Mercedes Gomez (download presentation file)

Mucosal Immunol. 2013 Jan;6(1):104-13. doi: 10.1038/mi.2012.53. Epub 2012 Jun 20.
Intestinal CD103(-) dendritic cells migrate in lymph and prime effector T cells.
Cerovic V, Houston SA, Scott CL, Aumeunier A, Yrlid U, Mowat AM, Milling SW.
PubMed Link - PDF (password)

J Exp Med. 2012 Aug 27;209(9):1595-609. doi: 10.1084/jem.20111453. Epub 2012 Aug 13.
IL-1β mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4(+) Th17 cells.
Coccia M, Harrison OJ, Schiering C, Asquith MJ, Becher B, Powrie F, Maloy KJ.
PubMed Link - PDF (password)

August 2012

Friday, August 31, 2012 - Melissa Lawson (download presentation file)

Science. 2012 Sep 21;337(6101):1553-6. Epub 2012 Aug 23.
Acute gastrointestinal infection induces long-lived microbiota-specific T cell responses.
Hand TW, Dos Santos LM, Bouladoux N, Molloy MJ, Pagán AJ, Pepper M, Maynard CL, Elson CO 3rd, Belkaid Y.
PubMed Link - PDF (password)

Science. 2012 Oct 5;338(6103):120-3. doi: 10.1126/science.1224820. Epub 2012 Aug 16.
Intestinal inflammation targets cancer-inducing activity of the microbiota.
Arthur JC, Perez-Chanona E, Mühlbauer M, Tomkovich S, Uronis JM, Fan TJ, Campbell BJ, Abujamel T, Dogan B, Rogers AB, Rhodes JM, Stintzi A, Simpson KW, Hansen JJ, Keku TO, Fodor AA, Jobin C.
PubMed Link - PDF (password)


Friday, August 24, 2012 - Yasmin Köller (download presentation file)

Immunity. 2012 Jul 27;37(1):171-86. doi: 10.1016/j.immuni.2012.05.020. Epub 2012 Jun 28.
Priming of natural killer cells by nonmucosal mononuclear phagocytes requires instructive signals from commensal microbiota.
Ganal SC, Sanos SL, Kallfass C, Oberle K, Johner C, Kirschning C, Lienenklaus S, Weiss S, Staeheli P, Aichele P, Diefenbach A.
PubMed Link - PDF (password)

Mucosal Immunol. 2012 Sep;5(5):501-12. doi: 10.1038/mi.2012.23. Epub 2012 Apr 11.
Targeted deletion of MyD88 in intestinal epithelial cells results in compromised antibacterial immunity associated with downregulation of polymeric immunoglobulin receptor, mucin-2, and antibacterial peptides.
Frantz AL, Rogier EW, Weber CR, Shen L, Cohen DA, Fenton LA, Bruno ME, Kaetzel CS.
PubMed Link - PDF (password)


Friday, August 10, 2012 - Julia Cahenzli (download presentation file)

Science. 2012 Aug 31;337(6098):1115-9. doi: 10.1126/science.1225152. Epub 2012 Jul 26.
Compartmentalized control of skin immunity by resident commensals.
Naik S, Bouladoux N, Wilhelm C, Molloy MJ, Salcedo R, Kastenmuller W, Deming C, Quinones M, Koo L, Conlan S, Spencer S, Hall JA, Dzutsev A, Kong H, Campbell DJ, Trinchieri G, Segre JA, Belkaid Y.
PubMed Link - PDF (password)

July 2012

Friday, July 27th, 2012 - William Kwong Chung (download presentation file)

Immunity. 2012 Jul 27;37(1):158-70. doi: 10.1016/j.immuni.2012.04.011. Epub 2012 Jun 14.
Commensal bacteria calibrate the activation threshold of innate antiviral immunity.
Abt MC, Osborne LC, Monticelli LA, Doering TA, Alenghat T, Sonnenberg GF, Paley MA, Antenus M, Williams KL, Erikson J, Wherry EJ, Artis D.
PubMed Link - PDF (password)

Cell. 2012 Jul 6;150(1):29-38. doi: 10.1016/j.cell.2012.05.031.
Extrathymic generation of regulatory T cells in placental mammals mitigates maternal-fetal conflict.
Samstein RM, Josefowicz SZ, Arvey A, Treuting PM, Rudensky AY. PubMed Link - PDF (password)


Friday, July 13th, 2012 - Mercedes Gomez (download presentation file) - ILC special

Nat Immunol. 2011 Apr;12(4):320-6. doi: 10.1038/ni.2002. Epub 2011 Feb 20.
RORγt+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota.
Sawa S, Lochner M, Satoh-Takayama N, Dulauroy S, Bérard M, Kleinschek M, Cua D, Di Santo JP, Eberl G.
PubMed Link - PDF (password) - Supplementary

Immunity. 2010 Nov 24;33(5):736-51. doi: 10.1016/j.immuni.2010.10.017.
Regulated expression of nuclear receptor RORγt confers distinct functional fates to NK cell receptor-expressing RORγt(+) innate lymphocytes.
Vonarbourg C, Mortha A, Bui VL, Hernandez PP, Kiss EA, Hoyler T, Flach M, Bengsch B, Thimme R, Hölscher C, Hönig M, Pannicke U, Schwarz K, Ware CF, Finke D, Diefenbach A.
PubMed Link - PDF (password) - Supplementary

Science. 2012 Jun 8;336(6086):1321-5. doi: 10.1126/science.1222551. Epub 2012 Jun 6.
Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria.
Sonnenberg GF, Monticelli LA, Alenghat T, Fung TC, Hutnick NA, Kunisawa J, Shibata N, Grunberg S, Sinha R, Zahm AM, Tardif MR, Sathaliyawala T, Kubota M, Farber DL, Collman RG, Shaked A, Fouser LA, Weiner DB, Tessier PA, Friedman JR, Kiyono H, Bushman FD, Chang KM, Artis D.
PubMed Link - PDF (password) - Supplementary

Science. 2010 Oct 29;330(6004):665-9. doi: 10.1126/science.1194597. Epub 2010 Sep 23.
Lineage relationship analysis of RORgammat+ innate lymphoid cells.
Sawa S, Cherrier M, Lochner M, Satoh-Takayama N, Fehling HJ, Langa F, Di Santo JP, Eberl G.
PubMed Link - PDF (password) - Supplementary

Immunity. 2008 Dec 19;29(6):958-70. doi: 10.1016/j.immuni.2008.11.001. Epub 2008 Dec 11.
Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense.
Satoh-Takayama N, Vosshenrich CA, Lesjean-Pottier S, Sawa S, Lochner M, Rattis F, Mention JJ, Thiam K, Cerf-Bensussan N, Mandelboim O, Eberl G, Di Santo JP.
PubMed Link - PDF (password) - Supplementary

Nat Immunol. 2009 Jan;10(1):83-91. doi: 10.1038/ni.1684. Epub 2008 Nov 23.
RORgammat and commensal microflora are required for the differentiation of mucosal interleukin 22-producing NKp46+ cells.
Sanos SL, Bui VL, Mortha A, Oberle K, Heners C, Johner C, Diefenbach A.
PubMed Link - PDF (password) - Supplementary

EMBO J. 2011 Jun 17;30(14):2934-47. doi: 10.1038/emboj.2011.201.
Identity, regulation and in vivo function of gut NKp46+RORγt+ and NKp46+RORγt- lymphoid cells.
Reynders A, Yessaad N, Vu Manh TP, Dalod M, Fenis A, Aubry C, Nikitas G, Escalière B, Renauld JC, Dussurget O, Cossart P, Lecuit M, Vivier E, Tomasello E.
PubMed Link - PDF (password) - Supplementary

Science. 2012 Apr 27;336(6080):489-93. doi: 10.1126/science.1219328. Epub 2012 Mar 22.
Microbial exposure during early life has persistent effects on natural killer T cell function.
Olszak T, An D, Zeissig S, Vera MP, Richter J, Franke A, Glickman JN, Siebert R, Baron RM, Kasper DL, Blumberg RS.
PubMed Link - PDF (password) - Supplementary


Friday, July. 06th, 2012 - Markus Geuking (download presentation file)

Cell. 2012 Jun 22;149(7):1578-93. doi: 10.1016/j.cell.2012.04.037.
Gut immune maturation depends on colonization with a host-specific microbiota.
Chung H, Pamp SJ, Hill JA, Surana NK, Edelman SM, Troy EB, Reading NC, Villablanca EJ, Wang S, Mora JR, Umesaki Y, Mathis D, Benoist C, Relman DA, Kasper DL.
PubMed Link - PDF (password)

Nature. 2012 Jul 5;487(7405):104-8. doi: 10.1038/nature11225.
Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice.
Devkota S, Wang Y, Musch MW, Leone V, Fehlner-Peach H, Nadimpalli A, Antonopoulos DA, Jabri B, Chang EB.
PubMed Link - PDF (password)

June 2012

Friday, June. 15th, 2012 - Hai Li (download presentation file)

Science. 2012 Jun 8;336(6086):1321-5. doi: 10.1126/science.1222551. Epub 2012 Jun 6.
Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria.
Sonnenberg GF, Monticelli LA, Alenghat T, Fung TC, Hutnick NA, Kunisawa J, Shibata N, Grunberg S, Sinha R, Zahm AM, Tardif MR, Sathaliyawala T, Kubota M, Farber DL, Collman RG, Shaked A, Fouser LA, Weiner DB, Tessier PA, Friedman JR, Kiyono H, Bushman FD, Chang KM, Artis D.
PubMed Link - PDF (password)

Nat Med. 2012 May;18(5):799-806. doi: 10.1038/nm.2729.
Lethal inflammasome activation by a multidrug-resistant pathobiont upon antibiotic disruption of the microbiota.
Ayres JS, Trinidad NJ, Vance RE.
PubMed Link - PDF (password)


Friday, June. 8th, 2012 - Mercedes Gomez (download presentation file)

J Clin Invest. 2012 May 1;122(5):1933-47. doi: 10.1172/JCI40591. Epub 2012 Apr 2.
MyD88 is critically involved in immune tolerance breakdown at environmental interfaces of Foxp3-deficient mice.
Rivas MN, Koh YT, Chen A, Nguyen A, Lee YH, Lawson G, Chatila TA.
PubMed Link - PDF (password)

Science. 2012 Apr 6;336(6077):91-5. doi: 10.1126/science.1218004. Epub 2012 Mar 1.
Interleukin-22 drives endogenous thymic regeneration in mice.
Dudakov JA, Hanash AM, Jenq RR, Young LF, Ghosh A, Singer NV, West ML, Smith OM, Holland AM, Tsai JJ, Boyd RL, van den Brink MR.
PubMed Link - PDF (password)


Friday, June. 1st, 2012 - Lawson Melissa (download presentation file)

Science. 2012 May 18;336(6083):911-5. doi: 10.1126/science.1219083.
Cost-benefit tradeoffs in engineered lac operons.
Eames M, Kortemme T.
PubMed Link - PDF (password)

Mucosal Immunol. 2012 Nov;5(6):623-34. doi: 10.1038/mi.2012.36. Epub 2012 May 23.
Regulatory role of suppressive motifs from commensal DNA.
Bouladoux N, Hall JA, Grainger JR, dos Santos LM, Kann MG, Nagarajan V, Verthelyi D, Belkaid Y.
PubMed Link - PDF (password)

May 2012

Friday, May. 25th, 2012 - Julia Cahenzli (download presentation file)

Immunity. 2012 May 25;36(5):821-33. doi: 10.1016/j.immuni.2012.03.021. Epub 2012 May 17.
Epithelial cell-specific Act1 adaptor mediates interleukin-25-dependent helminth expulsion through expansion of Lin(-)c-Kit(+) innate cell population.
Kang Z, Swaidani S, Yin W, Wang C, Barlow JL, Gulen MF, Bulek K, Do JS, Aronica M, McKenzie AN, Min B, Li X.

PubMed Link - PDF (password)
Proc Natl Acad Sci U S A. 2012 May 15;109(20):7622-9. doi: 10.1073/pnas.1205129109. Epub 2012 Apr 25.
Enhancement of hematopoiesis and lymphopoiesis in diet-induced obese mice.
Trottier MD, Naaz A, Li Y, Fraker PJ.
PubMed Link - PDF (password)


Friday, May. 18th, 2012 - Yasmin Köller (download presentation file)

Nat Med. 2012 May;18(5):751-8. doi: 10.1038/nm.2735.
Interleukin-25 induces type 2 cytokine production in a steroid-resistant interleukin-17RB+ myeloid population that exacerbates asthmatic pathology.
Petersen BC, Budelsky AL, Baptist AP, Schaller MA, Lukacs NW.
PubMed Link - PDF (password)

Science. 2012 Jun 8;336(6086):1325-9. doi: 10.1126/science.1222195. Epub 2012 May 10.
Regulated virulence controls the ability of a pathogen to compete with the gut microbiota.
Kamada N, Kim YG, Sham HP, Vallance BA, Puente JL, Martens EC, Núñez G.
PubMed Link - PDF (password)


Friday, May. 11th, 2012 - William Kwong Chung (download presentation file)

Nat Immunol. 2012 Apr 29;13(6):587-95. doi: 10.1038/ni.2286.
TGF-β and retinoic acid induce the microRNA miR-10a, which targets Bcl-6 and constrains the plasticity of helper T cells.
Takahashi H, Kanno T, Nakayamada S, Hirahara K, Sciumè G, Muljo SA, Kuchen S, Casellas R, Wei L, Kanno Y, O'Shea JJ.
PubMed Link - PDF (password)

Science. 2012 Apr 27;336(6080):485-9. doi: 10.1126/science.1217718.
The inhibitory receptor PD-1 regulates IgA selection and bacterial composition in the gut.
Kawamoto S, Tran TH, Maruya M, Suzuki K, Doi Y, Tsutsui Y, Kato LM, Fagarasan S.
PubMed Link - PDF (password)

April 2012

Friday, April. 27th, 2012 - Markus Geuking (download presentation file)

Nature. 2012 Apr 26;484(7395):514-8. doi: 10.1038/nature10957.
Pathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β.
Zielinski CE, Mele F, Aschenbrenner D, Jarrossay D, Ronchi F, Gattorno M, Monticelli S, Lanzavecchia A, Sallusto F.
PubMed Link - PDF (password)

Nat Immunol. 2012 May;13(5):449-56. doi: 10.1038/ni.2263.
NLRC4-driven production of IL-1β discriminates between pathogenic and commensal bacteria and promotes host intestinal defense.
Franchi L, Kamada N, Nakamura Y, Burberry A, Kuffa P, Suzuki S, Shaw MH, Kim YG, Núñez G.
PubMed Link - PDF (password)


Friday, April. 20th, 2012 - Mercedes Gomez (download presentation file)

Science. 2012 Apr 27;336(6080):489-93. doi: 10.1126/science.1219328. Epub 2012 Mar 22.
Microbial exposure during early life has persistent effects on natural killer T cell function.
Olszak T, An D, Zeissig S, Vera MP, Richter J, Franke A, Glickman JN, Siebert R, Baron RM, Kasper DL, Blumberg RS.
PubMed Link - PDF (password)

J Immunol. 2012 May 1;188(9):4315-22. doi: 10.4049/jimmunol.1103223. Epub 2012 Apr 4.
Infant B cell memory differentiation and early gut bacterial colonization.
Lundell AC, Björnsson V, Ljung A, Ceder M, Johansen S, Lindhagen G, Törnhage CJ, Adlerberth I, Wold AE, Rudin A.
PubMed Link - PDF (password)


Friday, April. 13th, 2012 - Hai Li (download presentation file)

Nat Med. 2012 Mar 25;18(4):538-46. doi: 10.1038/nm.2657.
Commensal bacteria-derived signals regulate basophil hematopoiesis and allergic inflammation.
Hill DA, Siracusa MC, Abt MC, Kim BS, Kobuley D, Kubo M, Kambayashi T, Larosa DF, Renner ED, Orange JS, Bushman FD, Artis D.
PubMed Link - PDF (password)

Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):5010-5. doi: 10.1073/pnas.1114931109. Epub 2012 Mar 7.
Intestinal CX3C chemokine receptor 1(high) (CX3CR1(high)) myeloid cells prevent T-cell-dependent colitis.
Kayama H, Ueda Y, Sawa Y, Jeon SG, Ma JS, Okumura R, Kubo A, Ishii M, Okazaki T, Murakami M, Yamamoto M, Yagita H, Takeda K.
PubMed Link - PDF (password)

March 2012

Friday, March. 30th, 2012 - Melissa Lawson (download presentation file)

J Immunol. 2012 Feb 1;188(3):1036-48. doi: 10.4049/jimmunol.1102500. Epub 2011 Dec 23.
Regulatory B10 cells differentiate into antibody-secreting cells after transient IL-10 production in vivo.
Maseda D, Smith SH, DiLillo DJ, Bryant JM, Candando KM, Weaver CT, Tedder TF.
PubMed Link - PDF (password)

Nature. 2012 Mar 14;483(7389):345-9. doi: 10.1038/nature10863.
Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine.
McDole JR, Wheeler LW, McDonald KG, Wang B, Konjufca V, Knoop KA, Newberry RD, Miller MJ.
PubMed Link - PDF (password)


Friday, March. 23rd, 2012 - Julia Cahenzli (download presentation file)

Nature. 2012 Feb 8;482(7385):395-9. doi: 10.1038/nature10772.
Extrathymically generated regulatory T cells control mucosal TH2 inflammation.
Josefowicz SZ, Niec RE, Kim HY, Treuting P, Chinen T, Zheng Y, Umetsu DT, Rudensky AY.
PubMed Link - PDF (password)

Immunity. 2012 Feb 24;36(2):228-38. doi: 10.1016/j.immuni.2011.11.019. Epub 2012 Feb 1.
B cell-intrinsic MyD88 signaling prevents the lethal dissemination of commensal bacteria during colonic damage.
Kirkland D, Benson A, Mirpuri J, Pifer R, Hou B, DeFranco AL, Yarovinsky F.
PubMed Link - PDF (password)


Friday, March. 9th, 2012 - William Kwong chung (download presentation file)

Immunity. 2012 Feb 24;36(2):262-75. doi: 10.1016/j.immuni.2011.12.012. Epub 2012 Feb 9.
Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells.
Miyao T, Floess S, Setoguchi R, Luche H, Fehling HJ, Waldmann H, Huehn J, Hori S.
PubMed Link - PDF (password)

J Exp Med. 2012 Feb 13;209(2):251-8. doi: 10.1084/jem.20111703. Epub 2012 Jan 30.
Microbiota-induced IL-1β, but not IL-6, is critical for the development of steady-state TH17 cells in the intestine.
Shaw MH, Kamada N, Kim YG, Núñez G.
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February 2012

Friday, Feb. 12th, 2012 - Mercedes Gomez (download presentation file)

J Exp Med. 2012 Jan 16;209(1):139-55. doi: 10.1084/jem.20101387. Epub 2012 Jan 9.
Inflammation switches the differentiation program of Ly6Chi monocytes from antiinflammatory macrophages to inflammatory dendritic cells in the colon.
Rivollier A, He J, Kole A, Valatas V, Kelsall BL.
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January 2012

Friday, January 26th, 2012 - Hai Li (download presentation file)

Science. 2011 Oct 14;334(6053):245-9. doi: 10.1126/science.1210718.
Successful transmission of a retrovirus depends on the commensal microbiota.
Kane M, Case LK, Kopaskie K, Kozlova A, MacDearmid C, Chervonsky AV, Golovkina TV.
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Nature. 2011 Oct 26;479(7374):538-41. doi: 10.1038/nature10554.
Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination.
Berer K, Mues M, Koutrolos M, Rasbi ZA, Boziki M, Johner C, Wekerle H, Krishnamoorthy G.
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Friday, January 19th, 2012 - Melissa Lawson (download presentation file)

Science. 2012 Feb 3;335(6068):597-601. doi: 10.1126/science.1215173. Epub 2012 Jan 12.
Innate response activator B cells protect against microbial sepsis.
Rauch PJ, Chudnovskiy A, Robbins CS, Weber GF, Etzrodt M, Hilgendorf I, Tiglao E, Figueiredo JL, Iwamoto Y, Theurl I, Gorbatov R, Waring MT, Chicoine AT, Mouded M, Pittet MJ, Nahrendorf M, Weissleder R, Swirski FK.
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PLoS Genet. 2011 Jun;7(6):e1002107. doi: 10.1371/journal.pgen.1002107. Epub 2011 Jun 16.
Trade-off between bile resistance and nutritional competence drives Escherichia coli diversification in the mouse gut.
De Paepe M, Gaboriau-Routhiau V, Rainteau D, Rakotobe S, Taddei F, Cerf-Bensussan N.
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Friday, January 13th, 2012 - Julia Cahenzli (download presentation file)

Nat Immunol. 2011 Dec 25;13(2):170-80. doi: 10.1038/ni.2194.
B cell-helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleen.
Puga I, Cols M, Barra CM, He B, Cassis L, Gentile M, Comerma L, Chorny A, Shan M, Xu W, Magri G, Knowles DM, Tam W, Chiu A, Bussel JB, Serrano S, Lorente JA, Bellosillo B, Lloreta J, Juanpere N, Alameda F, Baró T, de Heredia CD, Torán N, Català A, Torrebadell M, Fortuny C, Cusí V, Carreras C, Diaz GA, Blander JM, Farber CM, Silvestri G, Cunningham-Rundles C, Calvillo M, Dufour C, Notarangelo LD, Lougaris V, Plebani A, Casanova JL, Ganal SC, Diefenbach A, Aróstegui JI, Juan M, Yagüe J, Mahlaoui N, Donadieu J, Chen K, Cerutti A.
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Nat Immunol. 2011 Dec 4;13(1):58-66. doi: 10.1038/ni.2182. 
Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity.
Liang HE, Reinhardt RL, Bando JK, Sullivan BM, Ho IC, Locksley RM.
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